The Relationship of Anatomical and Functional Connectivity to Resting-State Connectivity in Primate Somatosensory Cortex

Zheng Wang, LiMin Chen, László Négyessy, RobertM Friedman, Arabinda Mishra, JohnC Gore, Anna Roe

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Studies of resting-state activity in the brain have provoked critical questions about the brain@s functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity and anatomical connectivity are much debated. To investigate these relationships, we have examined both anatomical and steady-state functional connectivity within the hand representation of primary somatosensory cortex (areas 3b and 1) in anesthetized squirrel monkeys. The comparison of three data sets (fMRI, electrophysiological, and anatomical) indicate two primary axes of information flow within the SI:prominent interdigit interactions within area 3b and predominantly homotopic interactions between area 3b and area 1. These data support a strikingly close relationship between baseline functional connectivity and anatomical connections. This study extends findings derived from large-scale cortical networks to the realm of local millimeter-scale networks

Original languageEnglish (US)
Pages (from-to)1116-1126
Number of pages11
JournalNeuron
Volume78
Issue number6
DOIs
StatePublished - Jun 19 2013
Externally publishedYes

Fingerprint

Somatosensory Cortex
Primates
Saimiri
Brain
Hand
Magnetic Resonance Imaging
Datasets

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The Relationship of Anatomical and Functional Connectivity to Resting-State Connectivity in Primate Somatosensory Cortex. / Wang, Zheng; Chen, LiMin; Négyessy, László; Friedman, RobertM; Mishra, Arabinda; Gore, JohnC; Roe, Anna.

In: Neuron, Vol. 78, No. 6, 19.06.2013, p. 1116-1126.

Research output: Contribution to journalArticle

Wang, Zheng ; Chen, LiMin ; Négyessy, László ; Friedman, RobertM ; Mishra, Arabinda ; Gore, JohnC ; Roe, Anna. / The Relationship of Anatomical and Functional Connectivity to Resting-State Connectivity in Primate Somatosensory Cortex. In: Neuron. 2013 ; Vol. 78, No. 6. pp. 1116-1126.
@article{bdb5addcecc948a8b344a5f92fb2c8e4,
title = "The Relationship of Anatomical and Functional Connectivity to Resting-State Connectivity in Primate Somatosensory Cortex",
abstract = "Studies of resting-state activity in the brain have provoked critical questions about the brain@s functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity and anatomical connectivity are much debated. To investigate these relationships, we have examined both anatomical and steady-state functional connectivity within the hand representation of primary somatosensory cortex (areas 3b and 1) in anesthetized squirrel monkeys. The comparison of three data sets (fMRI, electrophysiological, and anatomical) indicate two primary axes of information flow within the SI:prominent interdigit interactions within area 3b and predominantly homotopic interactions between area 3b and area 1. These data support a strikingly close relationship between baseline functional connectivity and anatomical connections. This study extends findings derived from large-scale cortical networks to the realm of local millimeter-scale networks",
author = "Zheng Wang and LiMin Chen and L{\'a}szl{\'o} N{\'e}gyessy and RobertM Friedman and Arabinda Mishra and JohnC Gore and Anna Roe",
year = "2013",
month = "6",
day = "19",
doi = "10.1016/j.neuron.2013.04.023",
language = "English (US)",
volume = "78",
pages = "1116--1126",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - The Relationship of Anatomical and Functional Connectivity to Resting-State Connectivity in Primate Somatosensory Cortex

AU - Wang, Zheng

AU - Chen, LiMin

AU - Négyessy, László

AU - Friedman, RobertM

AU - Mishra, Arabinda

AU - Gore, JohnC

AU - Roe, Anna

PY - 2013/6/19

Y1 - 2013/6/19

N2 - Studies of resting-state activity in the brain have provoked critical questions about the brain@s functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity and anatomical connectivity are much debated. To investigate these relationships, we have examined both anatomical and steady-state functional connectivity within the hand representation of primary somatosensory cortex (areas 3b and 1) in anesthetized squirrel monkeys. The comparison of three data sets (fMRI, electrophysiological, and anatomical) indicate two primary axes of information flow within the SI:prominent interdigit interactions within area 3b and predominantly homotopic interactions between area 3b and area 1. These data support a strikingly close relationship between baseline functional connectivity and anatomical connections. This study extends findings derived from large-scale cortical networks to the realm of local millimeter-scale networks

AB - Studies of resting-state activity in the brain have provoked critical questions about the brain@s functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity and anatomical connectivity are much debated. To investigate these relationships, we have examined both anatomical and steady-state functional connectivity within the hand representation of primary somatosensory cortex (areas 3b and 1) in anesthetized squirrel monkeys. The comparison of three data sets (fMRI, electrophysiological, and anatomical) indicate two primary axes of information flow within the SI:prominent interdigit interactions within area 3b and predominantly homotopic interactions between area 3b and area 1. These data support a strikingly close relationship between baseline functional connectivity and anatomical connections. This study extends findings derived from large-scale cortical networks to the realm of local millimeter-scale networks

UR - http://www.scopus.com/inward/record.url?scp=84879258015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879258015&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2013.04.023

DO - 10.1016/j.neuron.2013.04.023

M3 - Article

VL - 78

SP - 1116

EP - 1126

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 6

ER -