The relationship between umbilical cord length and chronic rheumatic heart disease: A prospective cohort study

Anna Goodman, Eero Kajantie, Clive Osmond, Johan Eriksson, Ilona Koupil, Kent Thornburg, David I. Phillips

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Background One previous, preliminary study reported that the length of the umbilical cord at birth is related to the risk of developing chronic rheumatic heart disease in later life. We sought to replicate this finding. Design Prospective, population-based birth cohort. Methods We traced 11,580 individuals born between 1915 and 1929 in Uppsala, Sweden. We identified cases with a main or secondary diagnosis of chronic rheumatic heart disease in the Swedish national inpatient, outpatient or death registers. Archived obstetric records provided data on umbilical cord length, gestational age, birthweight and placental weight. Results There were 136 patients with chronic rheumatic heart disease (72 men and 64 women) with a mean age at first hospital admission of 68 years (range 36-92). There was evidence of a positive association between umbilical cord length and risk of subsequent chronic rheumatic heart disease. The overall hazard ratio in the Swedish study (1.13, 95% confidence interval 1.01 to 1.27) was similar to that of the previous study, with some suggestion of larger effect in men than in women. No other birth characteristics were predictive except for weak evidence of a protective effect of higher birthweight in men. Conclusions People with longer umbilical cords at birth are more likely to develop chronic rheumatic heart disease in later life. As longer umbilical cords have more spiral arteries and a higher vascular resistance, we hypothesize that the increased pressure load on the heart leads to changes in endothelial biology and increased vulnerability to the autoimmune process initiated by infection with β-haemolytic streptococci.

    Original languageEnglish (US)
    Pages (from-to)1154-1160
    Number of pages7
    JournalEuropean Journal of Preventive Cardiology
    Volume22
    Issue number9
    DOIs
    StatePublished - Sep 12 2015

    Fingerprint

    Rheumatic Heart Disease
    Umbilical Cord
    Cohort Studies
    Prospective Studies
    Parturition
    Streptococcus
    Sweden
    Vascular Resistance
    Gestational Age
    Obstetrics
    Inpatients
    Outpatients
    Arteries
    Confidence Intervals
    Pressure
    Weights and Measures
    Infection
    Population

    Keywords

    • birthweight
    • developmental origins of health and disease
    • foetal programming
    • Rheumatic heart disease
    • umbilical cord

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Epidemiology

    Cite this

    The relationship between umbilical cord length and chronic rheumatic heart disease : A prospective cohort study. / Goodman, Anna; Kajantie, Eero; Osmond, Clive; Eriksson, Johan; Koupil, Ilona; Thornburg, Kent; Phillips, David I.

    In: European Journal of Preventive Cardiology, Vol. 22, No. 9, 12.09.2015, p. 1154-1160.

    Research output: Contribution to journalArticle

    Goodman, Anna ; Kajantie, Eero ; Osmond, Clive ; Eriksson, Johan ; Koupil, Ilona ; Thornburg, Kent ; Phillips, David I. / The relationship between umbilical cord length and chronic rheumatic heart disease : A prospective cohort study. In: European Journal of Preventive Cardiology. 2015 ; Vol. 22, No. 9. pp. 1154-1160.
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