The relationship between human fetal cardiovascular hemodynamics and serum erythropoietin levels in growth-restricted fetuses

Anna Girsen, Kaarin Mäkikallio, Vilho Hiilesmaa, Esa Hämäläinen, Kari Teramo, Juha Rasanen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: We hypothesized that in growth restricted fetuses, erythropoietin (EPO) secretion is increased in proportion to the severity of cardiovascular compromise. Study Design: Thirty-eight growth restricted fetuses underwent Doppler ultrasonography of cardiovascular hemodynamics. An umbilical artery (UA) blood sample was taken at delivery for EPO analysis. Group 1 fetuses (n=9) had normal UA and ductus venosus (DV) velocimetries. Group 2 fetuses (n=18) showed an abnormal UA and a normal DV velocimetry. Group 3 fetuses (n=11) had abnormal UA and DV velocimetries. Normal EPO values were determined in 19 uncomplicated pregnancies (control group). Results: In group 3, EPO levels were higher (Pth percentile EPO value in the control group. The corresponding incidences were 44% and 50% in groups 1 and 2. Fetuses with retrograde aortic isthmus net blood flow had greater (P

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Erythropoietin
Umbilical Arteries
Fetus
Hemodynamics
Rheology
Growth
Serum
Doppler Ultrasonography
Control Groups
Reference Values
Pregnancy
Incidence

Keywords

  • Doppler
  • erythropoietin
  • fetal growth restriction
  • placental insufficiency

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

The relationship between human fetal cardiovascular hemodynamics and serum erythropoietin levels in growth-restricted fetuses. / Girsen, Anna; Mäkikallio, Kaarin; Hiilesmaa, Vilho; Hämäläinen, Esa; Teramo, Kari; Rasanen, Juha.

In: American Journal of Obstetrics and Gynecology, Vol. 196, No. 5, 05.2007.

Research output: Contribution to journalArticle

Girsen, Anna ; Mäkikallio, Kaarin ; Hiilesmaa, Vilho ; Hämäläinen, Esa ; Teramo, Kari ; Rasanen, Juha. / The relationship between human fetal cardiovascular hemodynamics and serum erythropoietin levels in growth-restricted fetuses. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 196, No. 5.
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