The relationship between alpha asymmetry and ADHD depends on negative affect level and parenting practices

Brittany R. Alperin, Christiana J. Smith, Hanna C. Gustafsson, McKenzie T. Figuracion, Sarah Karalunas

Research output: Contribution to journalArticle

Abstract

Atypical frontal alpha asymmetry is associated with the approach/withdrawal and affective processes implicated in many psychiatric disorders. Rightward alpha asymmetry, associated with high approach, is a putative endophenotype for attention deficit/hyperactivity disorder (ADHD). However, findings are inconsistent, likely because of a failure to consider emotional heterogeneity within the ADHD population. In addition, how this putative risk marker interacts with environmental factors known to increase symptom severity, such as parenting practices, has not been examined. The current study examined patterns of alpha asymmetry in a large sample of adolescents with and without ADHD, including the moderating role of negative affect and inconsistent discipline. Resting-state EEG was recorded from 169 well-characterized adolescents (nADHD = 79). Semi-structured clinical interviews and well-validated rating scales were used to create composites for negative affect and inconsistent discipline. The relationship between alpha asymmetry and ADHD diagnosis was moderated by negative affect. Right asymmetry was present only for those with ADHD and low levels of negative affect. In addition, greater right alpha asymmetry predicted severity of ADHD symptoms for those with the disorder, but only in the context of inconsistent parenting practices. Results confirm right alpha asymmetry is a possible endophenotype in ADHD but highlight the need to consider emotional heterogeneity and how biological risk interacts with child environment in order to fully characterize its relationship to disorder liability and severity.

Original languageEnglish (US)
Pages (from-to)138-146
Number of pages9
JournalJournal of Psychiatric Research
Volume116
DOIs
StatePublished - Sep 1 2019

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Parenting
Attention Deficit Disorder with Hyperactivity
Endophenotypes
Psychiatry
Electroencephalography
Interviews
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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The relationship between alpha asymmetry and ADHD depends on negative affect level and parenting practices. / Alperin, Brittany R.; Smith, Christiana J.; Gustafsson, Hanna C.; Figuracion, McKenzie T.; Karalunas, Sarah.

In: Journal of Psychiatric Research, Vol. 116, 01.09.2019, p. 138-146.

Research output: Contribution to journalArticle

Alperin, Brittany R. ; Smith, Christiana J. ; Gustafsson, Hanna C. ; Figuracion, McKenzie T. ; Karalunas, Sarah. / The relationship between alpha asymmetry and ADHD depends on negative affect level and parenting practices. In: Journal of Psychiatric Research. 2019 ; Vol. 116. pp. 138-146.
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