The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors

R. M. Egeler, J. P. Neglia, M. Arico, B. E. Favara, A. Heitger, M. E. Nesbit, H. S. Nicholson

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The frequency of Langerhans cell histiocytosis (LCH) and a malignant neoplasm occurring in the same individual appears to be greater than previously recognized. To define the occurrence and the pattern of these events, a Study Group of the Histiocyte Society initiated a registry of patients in whom this association occurred synchronously or asynchronously. Evaluation of 54 patients detected two patterns of associations between LCH and other disorders. First, it is possible that therapy of LCH promotes a secondary malignancy. Second, it is possible that a genetic predisposition, with or without the immunosuppression associated therapy for the malignancy, plays a role in the development and expression of disseminated LCH. Data collected by the LCH-Malignancy Study Group may provide insights into the etiology and pathophysiology of LCH.

Original languageEnglish (US)
Pages (from-to)369-378
Number of pages10
JournalHematology/Oncology Clinics of North America
Volume12
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

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Langerhans Cell Histiocytosis
Lymphoma
Leukemia
Neoplasms
Play Therapy
Histiocytes
Genetic Predisposition to Disease
Immunosuppression
Registries

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Egeler, R. M., Neglia, J. P., Arico, M., Favara, B. E., Heitger, A., Nesbit, M. E., & Nicholson, H. S. (1998). The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors. Hematology/Oncology Clinics of North America, 12(2), 369-378. https://doi.org/10.1016/S0889-8588(05)70516-5

The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors. / Egeler, R. M.; Neglia, J. P.; Arico, M.; Favara, B. E.; Heitger, A.; Nesbit, M. E.; Nicholson, H. S.

In: Hematology/Oncology Clinics of North America, Vol. 12, No. 2, 1998, p. 369-378.

Research output: Contribution to journalArticle

Egeler, RM, Neglia, JP, Arico, M, Favara, BE, Heitger, A, Nesbit, ME & Nicholson, HS 1998, 'The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors', Hematology/Oncology Clinics of North America, vol. 12, no. 2, pp. 369-378. https://doi.org/10.1016/S0889-8588(05)70516-5
Egeler, R. M. ; Neglia, J. P. ; Arico, M. ; Favara, B. E. ; Heitger, A. ; Nesbit, M. E. ; Nicholson, H. S. / The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors. In: Hematology/Oncology Clinics of North America. 1998 ; Vol. 12, No. 2. pp. 369-378.
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