The regulatory role of DPP4 in atherosclerotic disease

Lihua Duan, Xiaoquan Rao, Chang Xia, Sanjay Rajagopalan, Jixin Zhong

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

The increasing prevalence of atherosclerosis has become a worldwide health concern. Although significant progress has been made in the understanding of atherosclerosis pathogenesis, the underlying mechanisms are not fully understood. Recent studies suggest dipeptidyl peptidase-4 (DPP4), a regulator of inflammation and metabolism, may be involved in the development of atherosclerotic diseases. There has been increasing clinical and pre-clinical evidence showing DPP4-incretin axis is involved in cardiovascular disease. Although the cardiovascular outcome of DPP4 inhibition or incretin analogues has been or being evaluated by several large scale clinical trials, the exact role of DPP4 in atherosclerotic diseases is not completely understood. In the current review, we will summarize the recent advances in direct and indirect regulatory role of DPP4 in atherosclerosis.

Original languageEnglish (US)
Article number76
JournalCardiovascular Diabetology
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

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Keywords

  • Atherosclerosis
  • Dipeptidyl peptidase
  • DPP4 inhibitor
  • Gliptins
  • Incretin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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