The question of whether or not there is a polymorphism in or near DRD2 which is associated with receptor density remains unanswered. Both clinical and animal data demonstrate that D2 dopamine receptor density is highly variable among individuals; differences of more than 100% are not uncommon. Among inbred mouse strains and F2 intercrosses produced from these strains, it appears that most of the genetic variation in receptor expression is not associated with polymorphisms in or near Drd2.
ASJC Scopus subject areas
- Molecular Biology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience