The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection

Nancy Linford, Christian Wade, Daniel Dorsa

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A review of the literature reveals an impressively broad spectrum of effects of the hormone estrogen in the CNS. One of the more recently documented is the ability of estrogen to protect neurons from cell death associated with a variety of insults. While some of these actions can be attributed to nuclear effects of the hormone, mediated by the estrogen receptors alpha and/or beta, an increasing number of these effects appear to result from actions of the hormone mediated by signal transduction pathways traditionally associated with activation of membrane receptors. Here, we review current findings on actions of estrogen mediated by two pathways: those dependent on cAMP and Protein Kinase A, and those related to activation of the Mitogen Acivated Protein Kinase cascade. The evidence that estrogen can rapidly activate either pathway, and the potential involvement of the estrogen receptors alpha or beta acting in the vicinity of the cell membrane will be discussed. The possible role of MAP-Kinase activation and BCL-2 induction in the phenomenon of estrogen-neuroprotection will also be addressed.

Original languageEnglish (US)
Pages (from-to)367-374
Number of pages8
JournalJournal of Neurocytology
Volume29
Issue number5-6
DOIs
StatePublished - 2000
Externally publishedYes

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Estrogens
Estrogen Receptor beta
Estrogen Receptor alpha
Hormones
Cyclic AMP-Dependent Protein Kinases
Mitogens
Protein Kinases
Signal Transduction
Cell Death
Phosphotransferases
Cell Membrane
Neuroprotection
Neurons
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Cell Biology
  • Histology

Cite this

The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection. / Linford, Nancy; Wade, Christian; Dorsa, Daniel.

In: Journal of Neurocytology, Vol. 29, No. 5-6, 2000, p. 367-374.

Research output: Contribution to journalArticle

Linford, Nancy ; Wade, Christian ; Dorsa, Daniel. / The rapid effects of estrogen are implicated in estrogen-mediated neuroprotection. In: Journal of Neurocytology. 2000 ; Vol. 29, No. 5-6. pp. 367-374.
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