The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study

Comparative effectiveness of a time-varying treatment with competing risks

John B. Holcomb, Deborah J. Del Junco, Erin E. Fox, Charles E. Wade, Mitchell J. Cohen, Martin Schreiber, Louis H. Alarcon, Yu Bai, Karen Brasel, Eileen M. Bulger, Bryan A. Cotton, Nena Matijevic, Peter Muskat, John G. Myers, Herb A. Phelan, Christopher E. White, Jiajie Zhang, Mohammad H. Rahbar

    Research output: Contribution to journalArticle

    384 Citations (Scopus)

    Abstract

    Objective: To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma: red blood cell (RBC) and platelet:RBC ratios. Design: Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using timedependent proportional hazards models. Setting: Ten US level I trauma centers. Patients: Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n=1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n=905, the analysis group). Main Outcome Measure: In-hospital mortality. Results: Plasma:RBC and platelet:RBC ratios were not constant during the first 24 hours (P

    Original languageEnglish (US)
    Pages (from-to)127-136
    Number of pages10
    JournalJAMA Surgery
    Volume148
    Issue number2
    DOIs
    StatePublished - Feb 2013

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    Blood Platelets
    Erythrocytes
    Wounds and Injuries
    Hospital Mortality
    Trauma Centers
    Therapeutics
    Proportional Hazards Models
    Resuscitation
    Cohort Studies
    Outcome Assessment (Health Care)
    Prospective Studies

    ASJC Scopus subject areas

    • Surgery

    Cite this

    The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study : Comparative effectiveness of a time-varying treatment with competing risks. / Holcomb, John B.; Del Junco, Deborah J.; Fox, Erin E.; Wade, Charles E.; Cohen, Mitchell J.; Schreiber, Martin; Alarcon, Louis H.; Bai, Yu; Brasel, Karen; Bulger, Eileen M.; Cotton, Bryan A.; Matijevic, Nena; Muskat, Peter; Myers, John G.; Phelan, Herb A.; White, Christopher E.; Zhang, Jiajie; Rahbar, Mohammad H.

    In: JAMA Surgery, Vol. 148, No. 2, 02.2013, p. 127-136.

    Research output: Contribution to journalArticle

    Holcomb, JB, Del Junco, DJ, Fox, EE, Wade, CE, Cohen, MJ, Schreiber, M, Alarcon, LH, Bai, Y, Brasel, K, Bulger, EM, Cotton, BA, Matijevic, N, Muskat, P, Myers, JG, Phelan, HA, White, CE, Zhang, J & Rahbar, MH 2013, 'The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: Comparative effectiveness of a time-varying treatment with competing risks', JAMA Surgery, vol. 148, no. 2, pp. 127-136. https://doi.org/10.1001/2013.jamasurg.387
    Holcomb, John B. ; Del Junco, Deborah J. ; Fox, Erin E. ; Wade, Charles E. ; Cohen, Mitchell J. ; Schreiber, Martin ; Alarcon, Louis H. ; Bai, Yu ; Brasel, Karen ; Bulger, Eileen M. ; Cotton, Bryan A. ; Matijevic, Nena ; Muskat, Peter ; Myers, John G. ; Phelan, Herb A. ; White, Christopher E. ; Zhang, Jiajie ; Rahbar, Mohammad H. / The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study : Comparative effectiveness of a time-varying treatment with competing risks. In: JAMA Surgery. 2013 ; Vol. 148, No. 2. pp. 127-136.
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    AU - Cohen, Mitchell J.

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    AU - Alarcon, Louis H.

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    AU - Cotton, Bryan A.

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    AU - White, Christopher E.

    AU - Zhang, Jiajie

    AU - Rahbar, Mohammad H.

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