The production, origin and role of dehydroepiandrosterone and Δ 5 androstenediol as androgen prehormones in hirsute women

M. A. Kirschner, S. Sinhamahapatra, I. R. Zucker, Donald (Lynn) Loriaux, E. Nieschiag

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Blood production rates (P(B)) of dehydroepiandrosterone (DHEA) and Δ 5 androstenediol (Δ 5 diol) were measured in a group of 22 women with hirsutism. The P(B)(DHEA) averaged 14.9 mg/day (2.5 times normal), and was reflected by differences in plasma DHEA concentrations, when compared with normal women. P(B)Δ 5 diol in the hirsute women averaged 1.27 mg/day and was also 2.5 fold elevated; however, since the metabolic clearance rates of Δ 5 diol were 2 fold elevated, the plasma Δ 5 diol levels in the hirsute group were only slightly high when compared with normal women. The peripheral metabolism of DHEA was investigated by determining its blood transfer constants (p) to Δ 5 diol, androstenedione (Δ 4 dione) and testosterone (T). Circulating DHEA accounted for 1/3 of the total Δ 5 diol produced in normal women, and for 1/2 of the Δ 5 diol produced in the hirsute group. DHEA accounted for 6-7% of Δ 4 dione in both normal and hirsute women. The p(BB)(DHEA→T) averaged 0.4% in normal women and 0.6% in hirsute women, thus accounting for only 82 μg/day or 8% of the total testosterone production in the latter group. Androstenediol metabolism was similarly examined by measuring its p constants to DHEA, Δ 4 dione and T. The p(BB)(Δ 5 diol→T) was 0.023 in normal women, and 0.011 in hirsute women, accounting for only 12-14 μg of P(B)(T) in both groups. Thus, neither DHEA nor Δ 5 diol were significant prehormones of testosterone in normal or hirsute women. Adrenal vein catheterizations revealed DHEA concentrations that were 110 times greater than peripheral blood, whereas ovarian venous effluents contained 6 fold gradients of DHEA. Thus, DHEA overproduction in hirsute women was largely adrenal in origin. Androstenediol gradients were noted in ovarian venous samples in 4 of 5 hirsute women.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume37
Issue number2
StatePublished - 1973
Externally publishedYes

Fingerprint

Androstenediol
Dehydroepiandrosterone
Androgens
Testosterone
Blood
Metabolism
Plasmas
Metabolic Clearance Rate
Androstenedione
Hirsutism
Effluents

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The production, origin and role of dehydroepiandrosterone and Δ 5 androstenediol as androgen prehormones in hirsute women. / Kirschner, M. A.; Sinhamahapatra, S.; Zucker, I. R.; Loriaux, Donald (Lynn); Nieschiag, E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 37, No. 2, 1973, p. 183-189.

Research output: Contribution to journalArticle

@article{93a8ba05b16a481580be10f565c23b67,
title = "The production, origin and role of dehydroepiandrosterone and Δ 5 androstenediol as androgen prehormones in hirsute women",
abstract = "Blood production rates (P(B)) of dehydroepiandrosterone (DHEA) and Δ 5 androstenediol (Δ 5 diol) were measured in a group of 22 women with hirsutism. The P(B)(DHEA) averaged 14.9 mg/day (2.5 times normal), and was reflected by differences in plasma DHEA concentrations, when compared with normal women. P(B)Δ 5 diol in the hirsute women averaged 1.27 mg/day and was also 2.5 fold elevated; however, since the metabolic clearance rates of Δ 5 diol were 2 fold elevated, the plasma Δ 5 diol levels in the hirsute group were only slightly high when compared with normal women. The peripheral metabolism of DHEA was investigated by determining its blood transfer constants (p) to Δ 5 diol, androstenedione (Δ 4 dione) and testosterone (T). Circulating DHEA accounted for 1/3 of the total Δ 5 diol produced in normal women, and for 1/2 of the Δ 5 diol produced in the hirsute group. DHEA accounted for 6-7{\%} of Δ 4 dione in both normal and hirsute women. The p(BB)(DHEA→T) averaged 0.4{\%} in normal women and 0.6{\%} in hirsute women, thus accounting for only 82 μg/day or 8{\%} of the total testosterone production in the latter group. Androstenediol metabolism was similarly examined by measuring its p constants to DHEA, Δ 4 dione and T. The p(BB)(Δ 5 diol→T) was 0.023 in normal women, and 0.011 in hirsute women, accounting for only 12-14 μg of P(B)(T) in both groups. Thus, neither DHEA nor Δ 5 diol were significant prehormones of testosterone in normal or hirsute women. Adrenal vein catheterizations revealed DHEA concentrations that were 110 times greater than peripheral blood, whereas ovarian venous effluents contained 6 fold gradients of DHEA. Thus, DHEA overproduction in hirsute women was largely adrenal in origin. Androstenediol gradients were noted in ovarian venous samples in 4 of 5 hirsute women.",
author = "Kirschner, {M. A.} and S. Sinhamahapatra and Zucker, {I. R.} and Loriaux, {Donald (Lynn)} and E. Nieschiag",
year = "1973",
language = "English (US)",
volume = "37",
pages = "183--189",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - The production, origin and role of dehydroepiandrosterone and Δ 5 androstenediol as androgen prehormones in hirsute women

AU - Kirschner, M. A.

AU - Sinhamahapatra, S.

AU - Zucker, I. R.

AU - Loriaux, Donald (Lynn)

AU - Nieschiag, E.

PY - 1973

Y1 - 1973

N2 - Blood production rates (P(B)) of dehydroepiandrosterone (DHEA) and Δ 5 androstenediol (Δ 5 diol) were measured in a group of 22 women with hirsutism. The P(B)(DHEA) averaged 14.9 mg/day (2.5 times normal), and was reflected by differences in plasma DHEA concentrations, when compared with normal women. P(B)Δ 5 diol in the hirsute women averaged 1.27 mg/day and was also 2.5 fold elevated; however, since the metabolic clearance rates of Δ 5 diol were 2 fold elevated, the plasma Δ 5 diol levels in the hirsute group were only slightly high when compared with normal women. The peripheral metabolism of DHEA was investigated by determining its blood transfer constants (p) to Δ 5 diol, androstenedione (Δ 4 dione) and testosterone (T). Circulating DHEA accounted for 1/3 of the total Δ 5 diol produced in normal women, and for 1/2 of the Δ 5 diol produced in the hirsute group. DHEA accounted for 6-7% of Δ 4 dione in both normal and hirsute women. The p(BB)(DHEA→T) averaged 0.4% in normal women and 0.6% in hirsute women, thus accounting for only 82 μg/day or 8% of the total testosterone production in the latter group. Androstenediol metabolism was similarly examined by measuring its p constants to DHEA, Δ 4 dione and T. The p(BB)(Δ 5 diol→T) was 0.023 in normal women, and 0.011 in hirsute women, accounting for only 12-14 μg of P(B)(T) in both groups. Thus, neither DHEA nor Δ 5 diol were significant prehormones of testosterone in normal or hirsute women. Adrenal vein catheterizations revealed DHEA concentrations that were 110 times greater than peripheral blood, whereas ovarian venous effluents contained 6 fold gradients of DHEA. Thus, DHEA overproduction in hirsute women was largely adrenal in origin. Androstenediol gradients were noted in ovarian venous samples in 4 of 5 hirsute women.

AB - Blood production rates (P(B)) of dehydroepiandrosterone (DHEA) and Δ 5 androstenediol (Δ 5 diol) were measured in a group of 22 women with hirsutism. The P(B)(DHEA) averaged 14.9 mg/day (2.5 times normal), and was reflected by differences in plasma DHEA concentrations, when compared with normal women. P(B)Δ 5 diol in the hirsute women averaged 1.27 mg/day and was also 2.5 fold elevated; however, since the metabolic clearance rates of Δ 5 diol were 2 fold elevated, the plasma Δ 5 diol levels in the hirsute group were only slightly high when compared with normal women. The peripheral metabolism of DHEA was investigated by determining its blood transfer constants (p) to Δ 5 diol, androstenedione (Δ 4 dione) and testosterone (T). Circulating DHEA accounted for 1/3 of the total Δ 5 diol produced in normal women, and for 1/2 of the Δ 5 diol produced in the hirsute group. DHEA accounted for 6-7% of Δ 4 dione in both normal and hirsute women. The p(BB)(DHEA→T) averaged 0.4% in normal women and 0.6% in hirsute women, thus accounting for only 82 μg/day or 8% of the total testosterone production in the latter group. Androstenediol metabolism was similarly examined by measuring its p constants to DHEA, Δ 4 dione and T. The p(BB)(Δ 5 diol→T) was 0.023 in normal women, and 0.011 in hirsute women, accounting for only 12-14 μg of P(B)(T) in both groups. Thus, neither DHEA nor Δ 5 diol were significant prehormones of testosterone in normal or hirsute women. Adrenal vein catheterizations revealed DHEA concentrations that were 110 times greater than peripheral blood, whereas ovarian venous effluents contained 6 fold gradients of DHEA. Thus, DHEA overproduction in hirsute women was largely adrenal in origin. Androstenediol gradients were noted in ovarian venous samples in 4 of 5 hirsute women.

UR - http://www.scopus.com/inward/record.url?scp=0015790533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015790533&partnerID=8YFLogxK

M3 - Article

C2 - 4268999

AN - SCOPUS:0015790533

VL - 37

SP - 183

EP - 189

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -