The price of emergency contraception in the United States: What is the cost-effectiveness of ulipristal acetate versus single-dose levonorgestrel?

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Ulipristal acetate (UPA) is a novel form of emergency contraception (EC) that appears to be more effective than the prevailing method, single-dose levonorgestrel (LNG). This study examines the cost-efficacy of UPA compared with LNG. Study Design: A decision-analytic model was developed to compare the cost-effectiveness of UPA versus LNG in preventing unintended pregnancy when taken within 120 h of unprotected intercourse. Univariate and bivariate sensitivity analyses, as well as Monte Carlo simulation and threshold analyses, were performed. Results: Utilizing UPA instead of LNG would result in 37,589 fewer unintended pregnancies per 4,176,572 estimated US annual EC uses (UPA 54,295 pregnancies; LNG 91,884 pregnancies) and a societal savings of $116.3 million annually. Cost-effectiveness acceptability curve analyses suggest a 96% probability that UPA is more cost-effective at a willingness to pay $100,000 per quality-adjusted life year. Conclusions: UPA is cost-effective in preventing unintended pregnancy after unprotected intercourse. Efforts should be promoted to increase access to UPA.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalContraception
Volume87
Issue number3
DOIs
StatePublished - Mar 1 2013

Keywords

  • Cost-effective analysis
  • Emergency contraception
  • Levonorgestrel
  • Ulipristal acetate

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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