The prevention of atherosclerosis with antioxidants

William Harris

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Recent research findings have suggested a role for pharmacologic as well as nutritional antioxidants in the prevention of atherosclerosis. Data from animal studies as well as cell culture experiments have shown that the drug probucol, which has hypocholesterolemic and antioxidant properties, is able to prevent oxidative modification of low density lipoproteins (LDL). Such modification is now believed to play a major part in the initiation and progression of arterial lesions. Nutrients with antioxidant properties such as vitamins C and E, beta-carotene, and monounsaturated fatty acids (when they replace polyunsaturated fatty acids) can reduce the susceptibility of LDL to oxidation. Antioxidant therapy, if proven useful, should be considered an adjunct to lipid-lowering therapy in order to have the greatest impact on coronary heart disease.

Original languageEnglish (US)
Pages (from-to)636-640
Number of pages5
JournalClinical Cardiology
Volume15
Issue number9
StatePublished - 1992
Externally publishedYes

Fingerprint

Atherosclerosis
Antioxidants
LDL Lipoproteins
Probucol
Monounsaturated Fatty Acids
beta Carotene
Unsaturated Fatty Acids
Vitamin E
Ascorbic Acid
Coronary Disease
Cell Culture Techniques
Lipids
Food
Therapeutics
Research
Pharmaceutical Preparations

Keywords

  • atherosclerosis
  • beta- carotene
  • hypercholesterolemia
  • hyperlipidemia
  • lipid oxidation
  • probucol
  • vitamin E

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The prevention of atherosclerosis with antioxidants. / Harris, William.

In: Clinical Cardiology, Vol. 15, No. 9, 1992, p. 636-640.

Research output: Contribution to journalArticle

Harris, W 1992, 'The prevention of atherosclerosis with antioxidants', Clinical Cardiology, vol. 15, no. 9, pp. 636-640.
Harris, William. / The prevention of atherosclerosis with antioxidants. In: Clinical Cardiology. 1992 ; Vol. 15, No. 9. pp. 636-640.
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