The prevalence of human herpesvirus-7 in renal transplant recipients is unaffected by oral or intravenous ganciclovir

Daniel C. Brennan, Gregory A. Storch, Gary G. Singer, Linda Lee, Jose Rueda, Mark A. Schnitzler

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of this study was to compare the prevalence of human herpesvirus (HHV)-7 and cytomegalovirus (CMV) viremia and the effects of oral and intravenous (iv) ganciclovir in renal transplant recipients at risk for CMV. Stored lysates from peripheral blood leukocytes from 92 patients, who had been previously analyzed for CMV viremia by polymerase chain reaction (PCR) for 12 weeks after transplantation, were analyzed for HHV-7 viremia. Baseline and peak prevalences of HHV-7 viremia were 22% and 54%, respectively (P <.0001). Eighty-two (89%) of 92 patients had at least 1 positive PCR for HHV-7. Oral ganciclovir and treatment with iv ganciclovir had no effect on the prevalence of HHV-7 viremia. In contrast, CMV was almost completely suppressed in patients who received oral ganciclovir, and when present, CMV responded to iv therapy. These results indicate that HHV-7 is resistant to ganciclovir at levels that were effective for prevention and treatment of CMV.

Original languageEnglish (US)
Pages (from-to)1557-1561
Number of pages5
JournalJournal of Infectious Diseases
Volume181
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

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Human Herpesvirus 7
Ganciclovir
Cytomegalovirus
Viremia
Kidney
Polymerase Chain Reaction
Transplant Recipients
Leukocytes
Therapeutics
Transplantation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The prevalence of human herpesvirus-7 in renal transplant recipients is unaffected by oral or intravenous ganciclovir. / Brennan, Daniel C.; Storch, Gregory A.; Singer, Gary G.; Lee, Linda; Rueda, Jose; Schnitzler, Mark A.

In: Journal of Infectious Diseases, Vol. 181, No. 5, 2000, p. 1557-1561.

Research output: Contribution to journalArticle

Brennan, Daniel C. ; Storch, Gregory A. ; Singer, Gary G. ; Lee, Linda ; Rueda, Jose ; Schnitzler, Mark A. / The prevalence of human herpesvirus-7 in renal transplant recipients is unaffected by oral or intravenous ganciclovir. In: Journal of Infectious Diseases. 2000 ; Vol. 181, No. 5. pp. 1557-1561.
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