The pressor effect of sodium-volume expansion is calcium mediated

J. P. Nicholson, L. M. Resnick, Joaquin Cigarroa, D. Marion, E. D. Vauhgan, J. H. Laragh

Research output: Contribution to journalArticle

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Abstract

To investigate the calcium dependence of salt-induced hypertension we concurrently measured blood pressure and serum ionized calcium in conscious normotensive female dogs undergoing five infusions: 1) sodium chloride (0.9% chloride, 2) calcium chloride (10 mg/kg), 3) combined sodium chloride and calcium chloride, 4) nicardipine (1 μg/kg/min), and 5) combined sodium chloride and calcium chloride in the presence of nicardipine. While saline and calcium chloride infusions individually did not affect blood pressure, saline combined with calcium chloride significantly and consistently raised mean arterial pressure (MAP) (ΔMAP = 7 ± 2 mm Hg, P <.001 v baseline). Serum ionized calcium (Ca(io)) levels increased within the normal range with the infusion of calcium alone (1.32 ± 0.03 to 1.48 ± 0.01 mmol/L, P <.005). Extracellular Ca(io) rose less with the combined NaCl-CaCl2 infusion (ΔCa(io) 0.10 ± 0.01 v 0.16 ± 0.02 mmol/L, P <.02). The difference in calcium elevations could not be attributed to volume expansion alone, since saline infusion itself did not affect serum ionized calcium (1.32 ± 0.3 to 1.31 ± 0.01 mmol/L, P = NS). Furthermore, nicardipine prevented the pressor effect of the combined saline-calcium infusion. (ΔMAP = -2 ± 3 v 7 ± 2 mm Hg, P <.001), and restored the rise in extracellular Ca(io) to that seen with the nonpressor calcium infusion (ΔCa(io) 0.15 ± 0.01 mmol/L v 0.16 ± 0.02 mmol/L, P = NS). Altogether, these data demonstrate that the rise in blood pressure and ionized calcium following an acute infusion of sodium and calcium chloride are interdependent. They further suggest the critical importance of cellular calcium uptake from the extracellular space as at least one mechanism by which sodium loading may elevate blood pressure.

Original languageEnglish (US)
Pages (from-to)904-908
Number of pages5
JournalAmerican Journal of Hypertension
Volume4
Issue number11
StatePublished - 1991
Externally publishedYes

Fingerprint

Sodium
Calcium Chloride
Calcium
Nicardipine
Sodium Chloride
Blood Pressure
Arterial Pressure
Serum
Extracellular Space
Chlorides
Reference Values
Salts
Dogs
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nicholson, J. P., Resnick, L. M., Cigarroa, J., Marion, D., Vauhgan, E. D., & Laragh, J. H. (1991). The pressor effect of sodium-volume expansion is calcium mediated. American Journal of Hypertension, 4(11), 904-908.

The pressor effect of sodium-volume expansion is calcium mediated. / Nicholson, J. P.; Resnick, L. M.; Cigarroa, Joaquin; Marion, D.; Vauhgan, E. D.; Laragh, J. H.

In: American Journal of Hypertension, Vol. 4, No. 11, 1991, p. 904-908.

Research output: Contribution to journalArticle

Nicholson, JP, Resnick, LM, Cigarroa, J, Marion, D, Vauhgan, ED & Laragh, JH 1991, 'The pressor effect of sodium-volume expansion is calcium mediated', American Journal of Hypertension, vol. 4, no. 11, pp. 904-908.
Nicholson JP, Resnick LM, Cigarroa J, Marion D, Vauhgan ED, Laragh JH. The pressor effect of sodium-volume expansion is calcium mediated. American Journal of Hypertension. 1991;4(11):904-908.
Nicholson, J. P. ; Resnick, L. M. ; Cigarroa, Joaquin ; Marion, D. ; Vauhgan, E. D. ; Laragh, J. H. / The pressor effect of sodium-volume expansion is calcium mediated. In: American Journal of Hypertension. 1991 ; Vol. 4, No. 11. pp. 904-908.
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