The prenatal origins of lung cancer. ii. the placenta

David J P Barker, Kent Thornburg, Clive Osmond, Eero Kajantie, Johan G. Eriksson

    Research output: Contribution to journalArticle

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    Abstract

    We have shown that people who were short at birth in relation to their weight are at increased risk of lung cancer. We suggested that this reflected low amino acid-high glucose delivery to the fetus and that this impaired the development of its antioxidant systems and made it vulnerable to tobacco smoke and other carcinogens in later life. Transfer of amino acids and glucose from mother to fetus depends on the placenta. We here examine how maternal and placental size are related to lung cancer. We studied two cohorts, totaling 20,431 people, born in Helsinki during 1924-1944. Their body size at birth and maternal body size had been recorded together with the weight of the placenta and two diameters of its surface. Of them, 385 had developed lung cancer. Three different maternal-placental-fetal phenotypes were associated with lung cancer. Common to each was a short mother and a newborn baby that was short in relation to its weight. Lung cancer was associated with either a small or a large placental surface area. In the three phenotypes, the hazard ratios associated with a 100 cm2 increase in placental surface were 0.36 (95% CI 0.14 to 0.87, P 5 0.02), 2.31 (1.45 to 3.69, P <0.001) and 2.04 (1.08 to 3.86, P 5 0.03). We conclude that three different maternal-placental phenotypes were associated with later lung cancer. We suggest that each led to low amino acid-normal glucose transfer to the fetus, reflected in a newborn baby that was short in relation to its weight. Am. J. Hum. Biol. 22:512-516, 2010.

    Original languageEnglish (US)
    Pages (from-to)512-516
    Number of pages5
    JournalAmerican Journal of Human Biology
    Volume22
    Issue number4
    DOIs
    StatePublished - Jul 2010

    Fingerprint

    lung neoplasms
    placenta
    Placenta
    cancer
    Lung Neoplasms
    Mothers
    fetus
    phenotype
    Weights and Measures
    glucose
    Fetus
    amino acid
    Body Size
    infants
    Phenotype
    Amino Acids
    Glucose
    baby
    amino acids
    body size

    ASJC Scopus subject areas

    • Anthropology
    • Anatomy
    • Genetics
    • Ecology, Evolution, Behavior and Systematics
    • Medicine(all)

    Cite this

    Barker, D. J. P., Thornburg, K., Osmond, C., Kajantie, E., & Eriksson, J. G. (2010). The prenatal origins of lung cancer. ii. the placenta. American Journal of Human Biology, 22(4), 512-516. https://doi.org/10.1002/ajhb.21041

    The prenatal origins of lung cancer. ii. the placenta. / Barker, David J P; Thornburg, Kent; Osmond, Clive; Kajantie, Eero; Eriksson, Johan G.

    In: American Journal of Human Biology, Vol. 22, No. 4, 07.2010, p. 512-516.

    Research output: Contribution to journalArticle

    Barker, DJP, Thornburg, K, Osmond, C, Kajantie, E & Eriksson, JG 2010, 'The prenatal origins of lung cancer. ii. the placenta', American Journal of Human Biology, vol. 22, no. 4, pp. 512-516. https://doi.org/10.1002/ajhb.21041
    Barker, David J P ; Thornburg, Kent ; Osmond, Clive ; Kajantie, Eero ; Eriksson, Johan G. / The prenatal origins of lung cancer. ii. the placenta. In: American Journal of Human Biology. 2010 ; Vol. 22, No. 4. pp. 512-516.
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