The preleukemic syndrome (hemopoietic dysplasia)

J. W. Linman, G. C. Bagby

    Research output: Contribution to journalArticle

    135 Citations (Scopus)

    Abstract

    Retrospective analysis of patient with acute myelomonoblastic (or nonlymphocytic) leukemia has helped to clarify the early stages of the evolution of this disease, and a clinical picture has emerged that is sufficiently discriminating to permit prospective observations. The clinical and laboratory features of the hematologic disorder preceding overt, blast-cell leukemia (i.e., the 'preleukemic syndrome' or 'hemopoietic dysplasia') are described, and diagnostic criteria and approaches to management are considered. This hematologic syndrome appears to be a stage in a multiphasic panmyelopathy that involves all products of the marrow stem cell. Available data indicate that most of these patients develop acute leukemia within 24 months of the onset of the hematologic abnormalities, but longer courses are not uncommon. Prospective documentation in a large group of patients is needed before the natural course can be accurately defined; such studies are now being planned.

    Original languageEnglish (US)
    Pages (from-to)854-864
    Number of pages11
    JournalCancer
    Volume42
    Issue number2 ,SUPPL.
    StatePublished - 1978

    Fingerprint

    Leukemia
    Documentation
    Stem Cells
    Bone Marrow

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology

    Cite this

    Linman, J. W., & Bagby, G. C. (1978). The preleukemic syndrome (hemopoietic dysplasia). Cancer, 42(2 ,SUPPL.), 854-864.

    The preleukemic syndrome (hemopoietic dysplasia). / Linman, J. W.; Bagby, G. C.

    In: Cancer, Vol. 42, No. 2 ,SUPPL., 1978, p. 854-864.

    Research output: Contribution to journalArticle

    Linman, JW & Bagby, GC 1978, 'The preleukemic syndrome (hemopoietic dysplasia)', Cancer, vol. 42, no. 2 ,SUPPL., pp. 854-864.
    Linman, J. W. ; Bagby, G. C. / The preleukemic syndrome (hemopoietic dysplasia). In: Cancer. 1978 ; Vol. 42, No. 2 ,SUPPL. pp. 854-864.
    @article{ce449a43779546fc9875af19772b2560,
    title = "The preleukemic syndrome (hemopoietic dysplasia)",
    abstract = "Retrospective analysis of patient with acute myelomonoblastic (or nonlymphocytic) leukemia has helped to clarify the early stages of the evolution of this disease, and a clinical picture has emerged that is sufficiently discriminating to permit prospective observations. The clinical and laboratory features of the hematologic disorder preceding overt, blast-cell leukemia (i.e., the 'preleukemic syndrome' or 'hemopoietic dysplasia') are described, and diagnostic criteria and approaches to management are considered. This hematologic syndrome appears to be a stage in a multiphasic panmyelopathy that involves all products of the marrow stem cell. Available data indicate that most of these patients develop acute leukemia within 24 months of the onset of the hematologic abnormalities, but longer courses are not uncommon. Prospective documentation in a large group of patients is needed before the natural course can be accurately defined; such studies are now being planned.",
    author = "Linman, {J. W.} and Bagby, {G. C.}",
    year = "1978",
    language = "English (US)",
    volume = "42",
    pages = "854--864",
    journal = "Cancer",
    issn = "0008-543X",
    publisher = "John Wiley and Sons Inc.",
    number = "2 ,SUPPL.",

    }

    TY - JOUR

    T1 - The preleukemic syndrome (hemopoietic dysplasia)

    AU - Linman, J. W.

    AU - Bagby, G. C.

    PY - 1978

    Y1 - 1978

    N2 - Retrospective analysis of patient with acute myelomonoblastic (or nonlymphocytic) leukemia has helped to clarify the early stages of the evolution of this disease, and a clinical picture has emerged that is sufficiently discriminating to permit prospective observations. The clinical and laboratory features of the hematologic disorder preceding overt, blast-cell leukemia (i.e., the 'preleukemic syndrome' or 'hemopoietic dysplasia') are described, and diagnostic criteria and approaches to management are considered. This hematologic syndrome appears to be a stage in a multiphasic panmyelopathy that involves all products of the marrow stem cell. Available data indicate that most of these patients develop acute leukemia within 24 months of the onset of the hematologic abnormalities, but longer courses are not uncommon. Prospective documentation in a large group of patients is needed before the natural course can be accurately defined; such studies are now being planned.

    AB - Retrospective analysis of patient with acute myelomonoblastic (or nonlymphocytic) leukemia has helped to clarify the early stages of the evolution of this disease, and a clinical picture has emerged that is sufficiently discriminating to permit prospective observations. The clinical and laboratory features of the hematologic disorder preceding overt, blast-cell leukemia (i.e., the 'preleukemic syndrome' or 'hemopoietic dysplasia') are described, and diagnostic criteria and approaches to management are considered. This hematologic syndrome appears to be a stage in a multiphasic panmyelopathy that involves all products of the marrow stem cell. Available data indicate that most of these patients develop acute leukemia within 24 months of the onset of the hematologic abnormalities, but longer courses are not uncommon. Prospective documentation in a large group of patients is needed before the natural course can be accurately defined; such studies are now being planned.

    UR - http://www.scopus.com/inward/record.url?scp=0018145514&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0018145514&partnerID=8YFLogxK

    M3 - Article

    VL - 42

    SP - 854

    EP - 864

    JO - Cancer

    JF - Cancer

    SN - 0008-543X

    IS - 2 ,SUPPL.

    ER -