The predictive value of inflammation-related peripheral blood measurements in cancer staging and prognosis

Joanna L. Sylman; Annachiara Mitrugno; Michelle Atallah; Garth W. Tormoen; Joseph J. Shatzel; Samuel Tassi Yunga; Todd H. Wagner; John T. Leppert; Parag Mallick; Owen J.T. McCarty

doi:10.3389/fonc.2018.00078

The predictive value of inflammation-related peripheral blood measurements in cancer staging and prognosis

Joanna L. Sylman, Annachiara Mitrugno, Michelle Atallah, Garth W. Tormoen, Joseph J. Shatzel, Samuel Tassi Yunga, Todd H. Wagner, John T. Leppert, Parag Mallick, Owen J.T. McCarty

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.

Original language	English (US)
Article number	78
Journal	Frontiers in Oncology
Volume	8
Issue number	MAR
DOIs	https://doi.org/10.3389/fonc.2018.00078
State	Published - Mar 21 2018

Keywords

Biomarkers
C-reactive protein
Cancer
Longitudinal
Neutrophil-to-lymphocyte
Platelet-to-lymphocyte
Prognosis

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2018.00078

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title = "The predictive value of inflammation-related peripheral blood measurements in cancer staging and prognosis",

abstract = "In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.",

keywords = "Biomarkers, C-reactive protein, Cancer, Longitudinal, Neutrophil-to-lymphocyte, Platelet-to-lymphocyte, Prognosis",

author = "Sylman, {Joanna L.} and Annachiara Mitrugno and Michelle Atallah and Tormoen, {Garth W.} and Shatzel, {Joseph J.} and Yunga, {Samuel Tassi} and Wagner, {Todd H.} and Leppert, {John T.} and Parag Mallick and McCarty, {Owen J.T.}",

note = "Publisher Copyright: {\textcopyright} 2018 Sylman, Mitrugno, Atallah, Tormoen, Shatzel, Tassi Yunga, Wagner, Leppert, Mallick and McCarty.",

year = "2018",

month = mar,

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doi = "10.3389/fonc.2018.00078",

language = "English (US)",

volume = "8",

journal = "Frontiers in Oncology",

issn = "2234-943X",

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T1 - The predictive value of inflammation-related peripheral blood measurements in cancer staging and prognosis

AU - Sylman, Joanna L.

AU - Mitrugno, Annachiara

AU - Atallah, Michelle

AU - Tormoen, Garth W.

AU - Shatzel, Joseph J.

AU - Yunga, Samuel Tassi

AU - Wagner, Todd H.

AU - Leppert, John T.

AU - Mallick, Parag

AU - McCarty, Owen J.T.

PY - 2018/3/21

Y1 - 2018/3/21

N2 - In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.

AB - In this review, we discuss the interaction between cancer and markers of inflammation (such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.

KW - Biomarkers

KW - C-reactive protein

KW - Cancer

KW - Longitudinal

KW - Neutrophil-to-lymphocyte

KW - Platelet-to-lymphocyte

KW - Prognosis

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DO - 10.3389/fonc.2018.00078

M3 - Review article

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VL - 8

JO - Frontiers in Oncology

JF - Frontiers in Oncology

IS - MAR

M1 - 78

ER -

The predictive value of inflammation-related peripheral blood measurements in cancer staging and prognosis

Abstract

Keywords

ASJC Scopus subject areas

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