The predictive validity of health-related quality of life measures: Mortality in a longitudinal population-based study

Mark S. Kaplan, Jean Marie Berthelot, David Feeny, Bentson H. McFarland, Saeeda Khan, Heather Orpana

Research output: Contribution to journalArticle

58 Scopus citations


Objective: This study examined the association between health-related quality of life (HRQL) and mortality risk, and compared the predictive ability of Health Utilities Index Mark 3 (HUI3) with self-rated health (SRH). Methods: Data were from the 1994/95 Canadian National Population Health Survey, consisting of 12,375 women and men aged 18 and older. Cox proportional hazards regression models were performed to estimate mortality risk over eight years. Results: Mortality risks for people reporting good, fair, and poor health at baseline were, respectively, 1.44 (95% confidence interval [CI] 1.04, 2.00), 1.97 (1.35, 2.88), and 3.21 (2.08, 4.95) times greater than those who reported excellent health. In a model excluding SRH, the effect of HUI3 on mortality was strong and significant (HR = 0.47; 95%, 0.33, 0.67) when adjusted for possible confounders. When HUI3 and SRH were considered simultaneously, the effect of the HUI3 on mortality was somewhat attenuated, but still significant (HR = 0.61, 0.42, 0.89) after adjusting for potential confounders. Conclusions: Although SRH is a modestly stronger predictor of mortality than HUI3, HUI3 adds to the mortality prediction ability of SRH.

Original languageEnglish (US)
Pages (from-to)1539-1546
Number of pages8
JournalQuality of Life Research
Issue number9
StatePublished - Nov 1 2007



  • Health Utilities Index Mark 3
  • Health-related quality of life
  • Longitudinal
  • Mortality
  • Mortality; Predictive validity
  • Self-rated health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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