The potential impact of antiretroviral therapy on fertility in sub-Saharan Africa

Angela Kaida, Irene Andia, Marissa Maier, Steffanie A. Strathdee, David R. Bangsberg, Jerry Spiegel, Francisco I. Bastos, Glenda Gray, Robert Hogg

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Approximately 14 million women of child-bearing age are living with HIV/AIDS in sub-Saharan Africa. Women with HIV infection have between 25% and 40% lower fertility than noninfected women. As antiretroviral (ARV) therapy becomes increasingly accessible in sub-Saharan Africa, it is important to understand whether and how the associated clinical improvements correspond with changes in the incidence of pregnancy and fertility. Accordingly, this paper reviews the literature on the potential impact of ARV therapy on the fertility of women with HIV infection in sub-Saharan Africa. We use Bongaarts' proximate determinants of fertility framework (adapted for conditions of a generalized HIV epidemic) to examine the underlying mechanisms through which use of ARV therapy may impact the fertility of women with HIV infection. A conceptual framework is proposed to guide future research aimed at understanding how widespread use of ARV therapy may impact fertility in sub-Saharan Africa.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalCurrent HIV/AIDS Reports
Volume3
Issue number4
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Kaida, A., Andia, I., Maier, M., Strathdee, S. A., Bangsberg, D. R., Spiegel, J., Bastos, F. I., Gray, G., & Hogg, R. (2006). The potential impact of antiretroviral therapy on fertility in sub-Saharan Africa. Current HIV/AIDS Reports, 3(4), 187-194. https://doi.org/10.1007/s11904-006-0015-0