The Portland Neurotoxicity Scale validation of a brief self-report measure of antiepileptic-drug-related neurotoxicity

Martin C. Salinsky, Daniel Storzbach

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The Portland Neurotoxicity Scale (PNS) is a brief patient-based survey of neurotoxicity complaints commonly encountered with the use of antiepileptic drugs (AEDs). The authors present data on the validity of this scale, particularly when used in longitudinal studies. Participants included 55 healthy controls, 23 epilepsy patient controls, and 86 healthy volunteers who took various AEDs or placebos for 12 weeks as part of randomized, double-blind studies of AED effects on cognitive abilities. Test-retest reliability in the control groups averaged .80 (total score). Test-retest changes in the PNS were sensitive to AED usage in general (p <.001 ) and to each of the five AEDs tested but not to placebo. Test-retest changes in the PNS were strongly correlated with several scales of the Profile of Mood States but only weakly correlated with objective cognitive test measures. The PNS has satisfactory psychometric properties and is sensitive to AED usage in test-retest studies.

Original languageEnglish (US)
Pages (from-to)107-117
Number of pages11
JournalAssessment
Volume12
Issue number1
DOIs
StatePublished - Mar 1 2005

Keywords

  • Antiepileptic drugs
  • Cognition
  • Neurotoxicity
  • Self-reporting

ASJC Scopus subject areas

  • Clinical Psychology
  • Applied Psychology

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