The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent

Kyle J. Miller, Ali A. Saherwala, Benjamin C. Webber, Yunkou Wu, A. Dean Sherry, Mark Woods

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.

Original languageEnglish (US)
Pages (from-to)8662-8664
Number of pages3
JournalInorganic Chemistry
Volume49
Issue number19
DOIs
StatePublished - Oct 4 2010

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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