The placental roots of cardiovascular disease

Kent Thornburg, Perrie F. O’Tierney, Terry Morgan, Samantha Louey

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    Introduction: Over the past 20 years the scientific literature has reported important relationships between placental size and augmented risk of cardiovascular disease in the offspring. The foundational paper that led to this idea was published by Barker and colleagues in 1989. They showed an inverse relationship between the mortality of men and women who lived in Hertfordshire, UK, and their weight at birth (Figure 16.1). This report was a landmark discovery; it showed clearly what many developmental biologists had previously noted – that the plastic nature of development underlies the lifelong health of the offspring. But this finding by Barker et al. was more specific. Birth weight was discovered to be a clear, statistically reliable predictor of death from one chronic disease condition. One exciting part of the birth weight story is the detective work from which it arose. Barker's team sought the culprit responsible for high death rates from ischaemic heart disease in the north of England. For them, the geographical map was as powerful as electrophoretic gel is for the molecular biologist. The team noticed that regions in England and Wales with high mortality rates from ischaemic heart disease overlapped perfectly regions with high rates of neonatal death (reviewed by Barker).

    Original languageEnglish (US)
    Title of host publicationThe Placenta and Human Developmental Programming
    PublisherCambridge University Press
    Pages201-215
    Number of pages15
    ISBN (Print)9780511933806, 9780521199452
    DOIs
    StatePublished - Jan 1 2010

    Fingerprint

    Birth Weight
    Cardiovascular Diseases
    England
    Myocardial Ischemia
    Mortality
    Literature
    Wales
    Plastics
    Chronic Disease
    Gels
    Health

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Thornburg, K., O’Tierney, P. F., Morgan, T., & Louey, S. (2010). The placental roots of cardiovascular disease. In The Placenta and Human Developmental Programming (pp. 201-215). Cambridge University Press. https://doi.org/10.1017/CBO9780511933806.017

    The placental roots of cardiovascular disease. / Thornburg, Kent; O’Tierney, Perrie F.; Morgan, Terry; Louey, Samantha.

    The Placenta and Human Developmental Programming. Cambridge University Press, 2010. p. 201-215.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Thornburg, K, O’Tierney, PF, Morgan, T & Louey, S 2010, The placental roots of cardiovascular disease. in The Placenta and Human Developmental Programming. Cambridge University Press, pp. 201-215. https://doi.org/10.1017/CBO9780511933806.017
    Thornburg K, O’Tierney PF, Morgan T, Louey S. The placental roots of cardiovascular disease. In The Placenta and Human Developmental Programming. Cambridge University Press. 2010. p. 201-215 https://doi.org/10.1017/CBO9780511933806.017
    Thornburg, Kent ; O’Tierney, Perrie F. ; Morgan, Terry ; Louey, Samantha. / The placental roots of cardiovascular disease. The Placenta and Human Developmental Programming. Cambridge University Press, 2010. pp. 201-215
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