The placental origins of sudden cardiac death

David J P Barker, Gail Larsen, Clive Osmond, Kent Thornburg, Eero Kajantie, Johan G. Eriksson

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    Objective: Most sudden cardiac deaths are due to cardiac arrhythmias, and abnormalities in the autonomic nervous system could underlie them. There is growing evidence that coronary heart disease is associated with alterations of fetal development as a result of variations in the processes of placentation that control fetal nutrition. We hypothesized that placental size would be associated with sudden cardiac death. Methods: We examined sudden cardiac death within the Helsinki Birth Cohort of 13 345 men and women. Results: One hundred eighty-seven (2.7%) men and 47 (0.7%) women had sudden unexplained cardiac death outside hospital. Sudden death was associated with a thin placenta, the hazard ratio being 1.47 [95% confidence interval (CI) 1.11-1.93, P = 0.006] for each g/cm2 decrease in thickness. Sudden death was independently associated with poor educational attainment (P <0.0001). Both of these associations were independent of socio-economic status in later life. Conclusion: Sudden death may be initiated by impaired development of the autonomic nervous system in utero as a result of shallow invasion of the spiral arteries in the maternal endometrium and consequent fetal malnutrition.

    Original languageEnglish (US)
    Article numberdys116
    Pages (from-to)1394-1399
    Number of pages6
    JournalInternational Journal of Epidemiology
    Volume41
    Issue number5
    DOIs
    StatePublished - Oct 2012

    Fingerprint

    Sudden Cardiac Death
    Sudden Death
    Autonomic Nervous System
    Fetal Nutrition Disorders
    Placentation
    Fetal Development
    Endometrium
    Placenta
    Coronary Disease
    Cardiac Arrhythmias
    Arteries
    Economics
    Mothers
    Parturition
    Confidence Intervals

    Keywords

    • Educational attainment
    • Placenta
    • Sudden cardiac death

    ASJC Scopus subject areas

    • Epidemiology

    Cite this

    Barker, D. J. P., Larsen, G., Osmond, C., Thornburg, K., Kajantie, E., & Eriksson, J. G. (2012). The placental origins of sudden cardiac death. International Journal of Epidemiology, 41(5), 1394-1399. [dys116]. https://doi.org/10.1093/ije/dys116

    The placental origins of sudden cardiac death. / Barker, David J P; Larsen, Gail; Osmond, Clive; Thornburg, Kent; Kajantie, Eero; Eriksson, Johan G.

    In: International Journal of Epidemiology, Vol. 41, No. 5, dys116, 10.2012, p. 1394-1399.

    Research output: Contribution to journalArticle

    Barker, DJP, Larsen, G, Osmond, C, Thornburg, K, Kajantie, E & Eriksson, JG 2012, 'The placental origins of sudden cardiac death', International Journal of Epidemiology, vol. 41, no. 5, dys116, pp. 1394-1399. https://doi.org/10.1093/ije/dys116
    Barker DJP, Larsen G, Osmond C, Thornburg K, Kajantie E, Eriksson JG. The placental origins of sudden cardiac death. International Journal of Epidemiology. 2012 Oct;41(5):1394-1399. dys116. https://doi.org/10.1093/ije/dys116
    Barker, David J P ; Larsen, Gail ; Osmond, Clive ; Thornburg, Kent ; Kajantie, Eero ; Eriksson, Johan G. / The placental origins of sudden cardiac death. In: International Journal of Epidemiology. 2012 ; Vol. 41, No. 5. pp. 1394-1399.
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