The placenta and human developmental programming

Graham J. Burton, David J.P. Barker, Ashley Moffett, Kent Thornburg

    Research output: Book/ReportBook

    31 Scopus citations

    Abstract

    Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.

    Original languageEnglish (US)
    PublisherCambridge University Press
    Number of pages254
    ISBN (Electronic)9780511933806
    ISBN (Print)9780521199452
    DOIs
    StatePublished - Jan 1 2010

    ASJC Scopus subject areas

    • Medicine(all)

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  • Cite this

    Burton, G. J., Barker, D. J. P., Moffett, A., & Thornburg, K. (2010). The placenta and human developmental programming. Cambridge University Press. https://doi.org/10.1017/CBO9780511933806