The phenogen informatics website: Tools for analyses of complex traits

Sanjiv V. Bhave, Cheryl Hornbaker, Tzu L. Phang, Laura Saba, Razvan Lapadat, Katherina Kechris, Jeanette Gaydos, Daniel McGoldrick, Andrew Dolbey, Sonia Leach, Brian Soriano, Allison Ellington, Eric Ellington, Kendra Jones, Jonathan Mangion, John K. Belknap, Robert W. Williams, Lawrence E. Hunter, Paula L. Hoffman, Boris Tabakoff

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Background: With the advent of "omics" (e.g. genomics, transcriptomics, proteomics and phenomics), studies can produce enormous amounts of data. Managing this diverse data and integrating with other biological data are major challenges for the bioinformatics community. Comprehensive new tools are needed to store, integrate and analyze the data efficiently. Description: The PhenoGen Informatics website http://phenogen.uchsc.edu is a comprehensive toolbox for storing, analyzing and integrating microarray data and related genotype and phenotype data. The site is particularly suited for combining QTL and microarray data to search for "candidate" genes contributing to complex traits. In addition, the site allows, if desired by the investigators, sharing of the data. Investigators can conduct "in-silico" microarray experiments using their own and/or "shared" data. Conclusion: The PhenoGen website provides access to tools that can be used for high-throughput data storage, analyses and interpretation of the results. Some of the advantages of the architecture of the website are that, in the future, the present set of tools can be adapted for the analyses of any type of high-throughput "omics" data, and that access to new tools, available in the public domain or developed at PhenoGen, can be easily provided.

Original languageEnglish (US)
Article number59
JournalBMC Genetics
Volume8
DOIs
StatePublished - Aug 29 2007

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Bhave, S. V., Hornbaker, C., Phang, T. L., Saba, L., Lapadat, R., Kechris, K., Gaydos, J., McGoldrick, D., Dolbey, A., Leach, S., Soriano, B., Ellington, A., Ellington, E., Jones, K., Mangion, J., Belknap, J. K., Williams, R. W., Hunter, L. E., Hoffman, P. L., & Tabakoff, B. (2007). The phenogen informatics website: Tools for analyses of complex traits. BMC Genetics, 8, [59]. https://doi.org/10.1186/1471-2156-8-59