The patterns of retinal ganglion cell death in hypertensive eyes

S. Laquis, P. Chaudhary, S. C. Sharma

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

We have recently described a rat model of hypertensive eye in which cauterizing limbal derived episcleral veins leads to increase in the intraocular pressure [S.R. Shareef, E. Garcia-Valenzuela, A. Salierno, J. Walsh, S.C. Sharma, Chronic ocular hypertension following episcleral venous occlusion in rats, Exp. Eye Res. 61 (1995) 379-382.]. We have further documented that retinal ganglion cell death is apoptotic [E. Garcia- Valenzuela, S. Shareef, J. Walsh, S.C. Sharma, Programmed cell death of retinal ganglion cells during experimental glaucoma, Exp. Eye Res. 61 (1995) 33-44.]. Here, we describe the total loss of retinal ganglion cells at various time intervals following increased IOP. At early time points death of ganglion cells in the central, peripheral retina occurred with similar frequencies. Between 4-6 weeks after intraocular elevation, ganglion cells in the peripheral retina were more susceptible than the central retina. Percentage of total ganglion cell death over the 10 week period was presumably linear and was about 4% per week.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalBrain research
Volume784
Issue number1-2
DOIs
StatePublished - Feb 16 1998

Keywords

  • Cell death
  • Hypertensive eyes
  • Intraocular pressure
  • Retina
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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