The 'open artery hypothesis' in survivors of myocardial infarction

William R. Pitts, Joaquin E. Cigarroa, Richard A. Lange, L. David Hillis

    Research output: Contribution to journalReview article

    2 Scopus citations

    Abstract

    In survivors of acute myocardial infarction, the restoration of antegrade flow in the infarct-related coronary artery may improve prognosis by a mechanism independent of its effect on left ventricular function. Survival may be enhanced even when restoration of flow is accomplished days or weeks after the acute event. In a series of retrospective studies of survivors of a first myocardial infarction, it was shown that long-term survival is significantly better in those with than in those without antegrade flow in the infarct-related artery. It is hypothesized that late restoration of antegrade flow in the infarct-related artery renders the border zone of the infarction more electrically stable, thereby diminishing the incidence of ventricular tachyarrhythmias and sudden death.

    Original languageEnglish (US)
    Pages (from-to)522-524
    Number of pages3
    JournalClinical Cardiology
    Volume20
    Issue number6
    DOIs
    StatePublished - 1997

    Keywords

    • Infarct artery
    • Patency

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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