The oncogenic properties of the HMG-I gene family

Lisa Wood, J. F. Maher, T. E. Bunton, L. M S Resar

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

The HMG-I gene family encodes high mobility group proteins originally identified as nonhistone chromosomal binding proteins. HMG-I and -Y proteins are alternatively spliced products of the same mRNA; HMG-C is encoded by a separate gene. The HMG-I proteins function as architectural chromatin-binding proteins that bind to the narrow groove of AT-rich regions in double-stranded DNA. Recent studies indicate an important role for HMG-I proteins in regulating gene expression. Moreover, increased expression of the HMG-I, -Y, and -C proteins correlates with cellular proliferation and neoplastic transformation in several cell types and human cancers. Previous work from our laboratory has shown that HMG-I is a direct c-Myc target gene that is involved in Myc-mediated neoplastic transformation. In this report, we show that increased expression of HMG-Y or -C leads to transformation with anchorage-independent cell growth in two experimental cell lines in a manner similar to that of HMG-I or c-Myc. Moreover, Rat 1a cells overexpressing HMG-Y or -C form tumors in nude mice analogous to Rat 1a cells overexpressing HMG-I or c-Myc. Distant metastases developed in animals injected with cells overexpressing HMG-I or -C. Our findings suggest that the HMG-I gene family is involved in neoplastic transformation and may represent a new family of oncogenes important in the pathogenesis of several human cancers.

Original languageEnglish (US)
Pages (from-to)4256-4261
Number of pages6
JournalCancer Research
Volume60
Issue number15
StatePublished - 2000
Externally publishedYes

Fingerprint

High Mobility Group Proteins
HMGA1a Protein
Genes
HMGA2 Protein
Carrier Proteins
Non Histone Chromosomal Proteins
AT Rich Sequence
Neoplasms
myc Genes
Oncogenes
Nude Mice
Chromatin
Cell Proliferation
Neoplasm Metastasis
Gene Expression
Cell Line
Messenger RNA
DNA
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wood, L., Maher, J. F., Bunton, T. E., & Resar, L. M. S. (2000). The oncogenic properties of the HMG-I gene family. Cancer Research, 60(15), 4256-4261.

The oncogenic properties of the HMG-I gene family. / Wood, Lisa; Maher, J. F.; Bunton, T. E.; Resar, L. M S.

In: Cancer Research, Vol. 60, No. 15, 2000, p. 4256-4261.

Research output: Contribution to journalArticle

Wood, L, Maher, JF, Bunton, TE & Resar, LMS 2000, 'The oncogenic properties of the HMG-I gene family', Cancer Research, vol. 60, no. 15, pp. 4256-4261.
Wood L, Maher JF, Bunton TE, Resar LMS. The oncogenic properties of the HMG-I gene family. Cancer Research. 2000;60(15):4256-4261.
Wood, Lisa ; Maher, J. F. ; Bunton, T. E. ; Resar, L. M S. / The oncogenic properties of the HMG-I gene family. In: Cancer Research. 2000 ; Vol. 60, No. 15. pp. 4256-4261.
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