The north American neuroendocrine tumor society consensus guidelines for surveillance and medical management of midgut neuroendocrine tumors

Jonathan R. Strosberg, Thorvardur R. Halfdanarson, Andrew M. Bellizzi, Jennifer A. Chan, Joseph S. Dillon, Anthony P. Heaney, Pamela L. Kunz, Thomas M. O'Dorisio, Riad Salem, Eva Segelov, James R. Howe, Rodney F. Pommier, Kari Brendtro, Mohammad A. Bashir, Simron Singh, Michael C. Soulen, Laura Tang, Jerome S. Zacks, James C. Yao, Emily K. Bergsland

    Research output: Contribution to journalArticlepeer-review

    97 Scopus citations

    Abstract

    There have been significant developments in diagnostic and therapeutic options for patients with neuroendocrine tumors (NETs). Key phase 3 studies include the CLARINET trial, which evaluated lanreotide in patients with nonfunctioning enteropancreatic NETs; the RADIANT-2 and RADIANT-4 studies, which evaluated everolimus in functioning and nonfunctioning NETs of the gastrointestinal tract and lungs; the TELESTAR study, which evaluated telotristat ethyl in patientswith refractory carcinoid syndrome; and the NETTER-1 trial, which evaluated 177Lu-DOTATATE in NETs of the small intestine and proximal colon (midgut). Based on these and other advances, the North American Neuroendocrine Tumor Society convened a multidisciplinary panel of experts with the goal of updating consensus-based guidelines for evaluation and treatment of midgut NETs. The medical aspects of these guidelines (focusing on systemic treatment, nonsurgical liver-directed therapy, and postoperative surveillance) are summarized in this article. Surgical guidelines are described in a companion article.

    Original languageEnglish (US)
    Pages (from-to)707-714
    Number of pages8
    JournalPancreas
    Volume46
    Issue number6
    DOIs
    StatePublished - 2017

    Keywords

    • Medical management
    • Midgut NETs
    • NANETS
    • Neuroendocrine tumor

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Hepatology
    • Endocrinology

    Fingerprint Dive into the research topics of 'The north American neuroendocrine tumor society consensus guidelines for surveillance and medical management of midgut neuroendocrine tumors'. Together they form a unique fingerprint.

    Cite this