The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits

M. S. Scheller, M. H. Zornow, J. E. Fleischer, G. T. Shearman, T. F. Greber

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-d-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.

Original languageEnglish (US)
Pages (from-to)677-681
Number of pages5
JournalNeuropharmacology
Volume28
Issue number7
DOIs
StatePublished - Jul 1989

Keywords

  • MK-801
  • N-methyl-d-aspartate receptor
  • halothane
  • isoflurane

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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