The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits

M. S. Scheller; M. H. Zornow; J. E. Fleischer; G. T. Shearman; T. F. Greber

doi:10.1016/0028-3908(89)90150-0

The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits

M. S. Scheller, M. H. Zornow, J. E. Fleischer, G. T. Shearman, T. F. Greber

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-d-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.

Original language	English (US)
Pages (from-to)	677-681
Number of pages	5
Journal	Neuropharmacology
Volume	28
Issue number	7
DOIs	https://doi.org/10.1016/0028-3908(89)90150-0
State	Published - Jul 1989
Externally published	Yes

Keywords

MK-801
N-methyl-d-aspartate receptor
halothane
isoflurane

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(89)90150-0

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title = "The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits",

abstract = "Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-d-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.",

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year = "1989",

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AU - Fleischer, J. E.

AU - Shearman, G. T.

AU - Greber, T. F.

PY - 1989/7

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N2 - Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-d-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.

AB - Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-d-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement to a noxious stimulus. It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia.

KW - MK-801

KW - N-methyl-d-aspartate receptor

KW - halothane

KW - isoflurane

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The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits

Abstract

Keywords

ASJC Scopus subject areas

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