The neurobiology of female puberty

Sergio Ojeda, Vincent Prevot, Sabine Heger, Alejandro Lomniczi, Barbara Dziedzic, Alison Mungenast

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    In this review, studies are described indicating that the increase in pulsatile release of gonadotropin releasing hormone that signals the initiation of puberty requires both changes in transsynaptic communication and the activation of glia-to-neuron signaling pathways. The major players in the transsynaptic control of puberty are neurons that utilize excitatory and inhibitory amino acids as transmitters. Glial cells employ a combination of trophic factors and small cell-cell signaling molecules to regulate neuronal function and thus promote sexual development. A neuron-to-glia signaling pathway mediated by excitatory amino acids serves to coordinate the simultaneous activation of transsynaptic and glia-to-neuron communication required for the advent of sexual maturity.

    Original languageEnglish (US)
    Pages (from-to)15-20
    Number of pages6
    JournalHormone Research
    Volume60
    Issue numberSUPPL. 3
    DOIs
    StatePublished - 2003

    Fingerprint

    Neurobiology
    Puberty
    Neuroglia
    Neurons
    Excitatory Amino Acids
    Sexual Development
    Gonadotropin-Releasing Hormone

    Keywords

    • Astroglial cells
    • Glial-neuronal communication
    • Growth factors
    • Hypothalamus
    • Onset of puberty
    • Sexual development

    ASJC Scopus subject areas

    • Endocrinology

    Cite this

    Ojeda, S., Prevot, V., Heger, S., Lomniczi, A., Dziedzic, B., & Mungenast, A. (2003). The neurobiology of female puberty. Hormone Research, 60(SUPPL. 3), 15-20. https://doi.org/10.1159/000074495

    The neurobiology of female puberty. / Ojeda, Sergio; Prevot, Vincent; Heger, Sabine; Lomniczi, Alejandro; Dziedzic, Barbara; Mungenast, Alison.

    In: Hormone Research, Vol. 60, No. SUPPL. 3, 2003, p. 15-20.

    Research output: Contribution to journalArticle

    Ojeda, S, Prevot, V, Heger, S, Lomniczi, A, Dziedzic, B & Mungenast, A 2003, 'The neurobiology of female puberty', Hormone Research, vol. 60, no. SUPPL. 3, pp. 15-20. https://doi.org/10.1159/000074495
    Ojeda S, Prevot V, Heger S, Lomniczi A, Dziedzic B, Mungenast A. The neurobiology of female puberty. Hormone Research. 2003;60(SUPPL. 3):15-20. https://doi.org/10.1159/000074495
    Ojeda, Sergio ; Prevot, Vincent ; Heger, Sabine ; Lomniczi, Alejandro ; Dziedzic, Barbara ; Mungenast, Alison. / The neurobiology of female puberty. In: Hormone Research. 2003 ; Vol. 60, No. SUPPL. 3. pp. 15-20.
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