The neu gene

An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

Alan L. Schechter, Mien Chie Hung, Lalitha Vaidyanathan, Robert A. Weinberg, Teresa L. Yang-Feng, Uta Francke, Axel Ullrich, Lisa Coussens

Research output: Contribution to journalArticle

388 Citations (Scopus)

Abstract

The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.

Original languageEnglish (US)
Pages (from-to)976-978
Number of pages3
JournalScience
Volume229
Issue number4717
StatePublished - 1985
Externally publishedYes

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erbB Genes
erbB-2 Genes
Epidermal Growth Factor Receptor
Ethylnitrosourea
Chromosomes, Human, Pair 17
Human Chromosomes
Oncogenes
Protein-Tyrosine Kinases
Genes
Genome
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Schechter, A. L., Hung, M. C., Vaidyanathan, L., Weinberg, R. A., Yang-Feng, T. L., Francke, U., ... Coussens, L. (1985). The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science, 229(4717), 976-978.

The neu gene : An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. / Schechter, Alan L.; Hung, Mien Chie; Vaidyanathan, Lalitha; Weinberg, Robert A.; Yang-Feng, Teresa L.; Francke, Uta; Ullrich, Axel; Coussens, Lisa.

In: Science, Vol. 229, No. 4717, 1985, p. 976-978.

Research output: Contribution to journalArticle

Schechter, AL, Hung, MC, Vaidyanathan, L, Weinberg, RA, Yang-Feng, TL, Francke, U, Ullrich, A & Coussens, L 1985, 'The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor', Science, vol. 229, no. 4717, pp. 976-978.
Schechter AL, Hung MC, Vaidyanathan L, Weinberg RA, Yang-Feng TL, Francke U et al. The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science. 1985;229(4717):976-978.
Schechter, Alan L. ; Hung, Mien Chie ; Vaidyanathan, Lalitha ; Weinberg, Robert A. ; Yang-Feng, Teresa L. ; Francke, Uta ; Ullrich, Axel ; Coussens, Lisa. / The neu gene : An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. In: Science. 1985 ; Vol. 229, No. 4717. pp. 976-978.
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