The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

Alan L. Schechter; Mien Chie Hung; Lalitha Vaidyanathan; Robert A. Weinberg; Teresa L. Yang-Feng; Uta Francke; Axel Ullrich; Lisa Coussens

doi:10.1126/science.2992090

The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

Alan L. Schechter, Mien Chie Hung, Lalitha Vaidyanathan, Robert A. Weinberg, Teresa L. Yang-Feng, Uta Francke, Axel Ullrich, Lisa Coussens

Research output: Contribution to journal › Article › peer-review

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Abstract

The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.

Original language	English (US)
Pages (from-to)	976-978
Number of pages	3
Journal	Science
Volume	229
Issue number	4717
DOIs	https://doi.org/10.1126/science.2992090
State	Published - 1985
Externally published	Yes

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title = "The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor",

abstract = "The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.",

author = "Schechter, {Alan L.} and Hung, {Mien Chie} and Lalitha Vaidyanathan and Weinberg, {Robert A.} and Yang-Feng, {Teresa L.} and Uta Francke and Axel Ullrich and Lisa Coussens",

year = "1985",

doi = "10.1126/science.2992090",

language = "English (US)",

volume = "229",

pages = "976--978",

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T2 - An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

AU - Schechter, Alan L.

AU - Hung, Mien Chie

AU - Vaidyanathan, Lalitha

AU - Weinberg, Robert A.

AU - Yang-Feng, Teresa L.

AU - Francke, Uta

AU - Ullrich, Axel

AU - Coussens, Lisa

PY - 1985

Y1 - 1985

N2 - The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.

AB - The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.

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ER -

The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

Abstract

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