The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

Alan L. Schechter, Mien Chie Hung, Lalitha Vaidyanathan, Robert A. Weinberg, Teresa L. Yang-Feng, Uta Francke, Axel Ullrich, Lisa Coussens

Research output: Contribution to journalArticle

391 Scopus citations

Abstract

The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.

Original languageEnglish (US)
Pages (from-to)976-978
Number of pages3
JournalScience
Volume229
Issue number4717
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

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    Schechter, A. L., Hung, M. C., Vaidyanathan, L., Weinberg, R. A., Yang-Feng, T. L., Francke, U., Ullrich, A., & Coussens, L. (1985). The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science, 229(4717), 976-978. https://doi.org/10.1126/science.2992090