The national consortium on alcohol and neuro-development in adolescence (NCANDA)

A multisite study of adolescent development and substance use

Sandra A. Brown, Ty Brumback, Kristin Tomlinson, Kevin Cummins, Wesley K. Thompson, Bonnie Nagel, Michael D. De Bellis, Stephen R. Hooper, Duncan B. Clark, Tammy Chung, Brant P. Hasler, Ian M. Colrain, Fiona C. Baker, Devin Prouty, Adolf Pfefferbaum, Edith V. Sullivan, Kilian M. Pohl, Torsten Rohlfing, B. Nolan Nichols, Weiwei Chu & 1 others Susan F. Tapert

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: During adolescence, neurobiological maturation occurs concurrently with social and interpersonal changes, including the initiation of alcohol and other substance use. The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) is designed to disentangle the complex relationships between onset, escalation, and desistance of alcohol use and changes in neurocognitive functioning and neuromaturation. Method: A sample of 831 youth, ages 12-21 years, was recruited at five sites across the United States, oversampling those at risk for alcohol use problems. Most (83%) had limited or no history of alcohol or other drug use, and a smaller portion (17%) exceeded drinking thresholds. A comprehensive assessment of biological development, family background, psychiatric symptomatology, and neuropsychological functioning-in addition to anatomical, diffusion, and functional brain magnetic resonance imaging-was completed at baseline. Results: The NCANDA sample of youth is nationally representative of sex and racial/ethnic groups. More than 50% have at least one risk characteristic for subsequent heavy drinking (e.g., family history, internalizing or externalizing symptoms). As expected, those who exceeded drinking thresholds (n = 139) differ from those who did not (n = 692) on identified factors associated with early alcohol use and problems. Conclusions: NCANDA successfully recruited a large sample of adolescents and comprehensively assessed psychosocial functioning across multiple domains. Based on the sample’s risk profile, NCANDA is well positioned to capture the transition into drinking and alcohol problems in a large portion of the cohort, as well as to help disentangle the associations between alcohol use, neurobiological maturation, and neurocognitive development and functioning.

Original languageEnglish (US)
Pages (from-to)895-908
Number of pages14
JournalJournal of Studies on Alcohol and Drugs
Volume76
Issue number6
DOIs
StatePublished - Nov 1 2015

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Adolescent Development
adolescence
alcohol
Alcohols
adolescent
Drinking
escalation
Ethnic Groups
Magnetic resonance
Alcohol Drinking
genealogy
Psychiatry
drug use
Brain
brain
ethnic group
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Health(social science)
  • Psychiatry and Mental health
  • Toxicology

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The national consortium on alcohol and neuro-development in adolescence (NCANDA) : A multisite study of adolescent development and substance use. / Brown, Sandra A.; Brumback, Ty; Tomlinson, Kristin; Cummins, Kevin; Thompson, Wesley K.; Nagel, Bonnie; De Bellis, Michael D.; Hooper, Stephen R.; Clark, Duncan B.; Chung, Tammy; Hasler, Brant P.; Colrain, Ian M.; Baker, Fiona C.; Prouty, Devin; Pfefferbaum, Adolf; Sullivan, Edith V.; Pohl, Kilian M.; Rohlfing, Torsten; Nichols, B. Nolan; Chu, Weiwei; Tapert, Susan F.

In: Journal of Studies on Alcohol and Drugs, Vol. 76, No. 6, 01.11.2015, p. 895-908.

Research output: Contribution to journalArticle

Brown, SA, Brumback, T, Tomlinson, K, Cummins, K, Thompson, WK, Nagel, B, De Bellis, MD, Hooper, SR, Clark, DB, Chung, T, Hasler, BP, Colrain, IM, Baker, FC, Prouty, D, Pfefferbaum, A, Sullivan, EV, Pohl, KM, Rohlfing, T, Nichols, BN, Chu, W & Tapert, SF 2015, 'The national consortium on alcohol and neuro-development in adolescence (NCANDA): A multisite study of adolescent development and substance use', Journal of Studies on Alcohol and Drugs, vol. 76, no. 6, pp. 895-908. https://doi.org/10.15288/jsad.2015.76.895
Brown, Sandra A. ; Brumback, Ty ; Tomlinson, Kristin ; Cummins, Kevin ; Thompson, Wesley K. ; Nagel, Bonnie ; De Bellis, Michael D. ; Hooper, Stephen R. ; Clark, Duncan B. ; Chung, Tammy ; Hasler, Brant P. ; Colrain, Ian M. ; Baker, Fiona C. ; Prouty, Devin ; Pfefferbaum, Adolf ; Sullivan, Edith V. ; Pohl, Kilian M. ; Rohlfing, Torsten ; Nichols, B. Nolan ; Chu, Weiwei ; Tapert, Susan F. / The national consortium on alcohol and neuro-development in adolescence (NCANDA) : A multisite study of adolescent development and substance use. In: Journal of Studies on Alcohol and Drugs. 2015 ; Vol. 76, No. 6. pp. 895-908.
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abstract = "Objective: During adolescence, neurobiological maturation occurs concurrently with social and interpersonal changes, including the initiation of alcohol and other substance use. The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) is designed to disentangle the complex relationships between onset, escalation, and desistance of alcohol use and changes in neurocognitive functioning and neuromaturation. Method: A sample of 831 youth, ages 12-21 years, was recruited at five sites across the United States, oversampling those at risk for alcohol use problems. Most (83{\%}) had limited or no history of alcohol or other drug use, and a smaller portion (17{\%}) exceeded drinking thresholds. A comprehensive assessment of biological development, family background, psychiatric symptomatology, and neuropsychological functioning-in addition to anatomical, diffusion, and functional brain magnetic resonance imaging-was completed at baseline. Results: The NCANDA sample of youth is nationally representative of sex and racial/ethnic groups. More than 50{\%} have at least one risk characteristic for subsequent heavy drinking (e.g., family history, internalizing or externalizing symptoms). As expected, those who exceeded drinking thresholds (n = 139) differ from those who did not (n = 692) on identified factors associated with early alcohol use and problems. Conclusions: NCANDA successfully recruited a large sample of adolescents and comprehensively assessed psychosocial functioning across multiple domains. Based on the sample’s risk profile, NCANDA is well positioned to capture the transition into drinking and alcohol problems in a large portion of the cohort, as well as to help disentangle the associations between alcohol use, neurobiological maturation, and neurocognitive development and functioning.",
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AU - Tomlinson, Kristin

AU - Cummins, Kevin

AU - Thompson, Wesley K.

AU - Nagel, Bonnie

AU - De Bellis, Michael D.

AU - Hooper, Stephen R.

AU - Clark, Duncan B.

AU - Chung, Tammy

AU - Hasler, Brant P.

AU - Colrain, Ian M.

AU - Baker, Fiona C.

AU - Prouty, Devin

AU - Pfefferbaum, Adolf

AU - Sullivan, Edith V.

AU - Pohl, Kilian M.

AU - Rohlfing, Torsten

AU - Nichols, B. Nolan

AU - Chu, Weiwei

AU - Tapert, Susan F.

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N2 - Objective: During adolescence, neurobiological maturation occurs concurrently with social and interpersonal changes, including the initiation of alcohol and other substance use. The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) is designed to disentangle the complex relationships between onset, escalation, and desistance of alcohol use and changes in neurocognitive functioning and neuromaturation. Method: A sample of 831 youth, ages 12-21 years, was recruited at five sites across the United States, oversampling those at risk for alcohol use problems. Most (83%) had limited or no history of alcohol or other drug use, and a smaller portion (17%) exceeded drinking thresholds. A comprehensive assessment of biological development, family background, psychiatric symptomatology, and neuropsychological functioning-in addition to anatomical, diffusion, and functional brain magnetic resonance imaging-was completed at baseline. Results: The NCANDA sample of youth is nationally representative of sex and racial/ethnic groups. More than 50% have at least one risk characteristic for subsequent heavy drinking (e.g., family history, internalizing or externalizing symptoms). As expected, those who exceeded drinking thresholds (n = 139) differ from those who did not (n = 692) on identified factors associated with early alcohol use and problems. Conclusions: NCANDA successfully recruited a large sample of adolescents and comprehensively assessed psychosocial functioning across multiple domains. Based on the sample’s risk profile, NCANDA is well positioned to capture the transition into drinking and alcohol problems in a large portion of the cohort, as well as to help disentangle the associations between alcohol use, neurobiological maturation, and neurocognitive development and functioning.

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