The myoD gene family: Nodal point during specification of the muscle cell lineage

Harold Weintraub, Robert Davis, Stephen Tapscott, Mathew (Matt) Thayer, Michael Krause, Robert Benezra, T. Keith Blackwell, David Turner, Ralph Rupp, Stanley Hollenberg, Yuan Zhuang, Andrew Lassar

Research output: Contribution to journalArticle

1158 Citations (Scopus)

Abstract

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loophelix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

Original languageEnglish (US)
Pages (from-to)761-766
Number of pages6
JournalScience
Volume251
Issue number4995
StatePublished - Feb 15 1991
Externally publishedYes

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Muscle Development
Dimerization
Cell Lineage
Muscle Cells
Helix-Loop-Helix Motifs
Genes
Skeletal Muscle
Amino Acids
Muscles
Proteins

ASJC Scopus subject areas

  • General

Cite this

Weintraub, H., Davis, R., Tapscott, S., Thayer, M. M., Krause, M., Benezra, R., ... Lassar, A. (1991). The myoD gene family: Nodal point during specification of the muscle cell lineage. Science, 251(4995), 761-766.

The myoD gene family : Nodal point during specification of the muscle cell lineage. / Weintraub, Harold; Davis, Robert; Tapscott, Stephen; Thayer, Mathew (Matt); Krause, Michael; Benezra, Robert; Blackwell, T. Keith; Turner, David; Rupp, Ralph; Hollenberg, Stanley; Zhuang, Yuan; Lassar, Andrew.

In: Science, Vol. 251, No. 4995, 15.02.1991, p. 761-766.

Research output: Contribution to journalArticle

Weintraub, H, Davis, R, Tapscott, S, Thayer, MM, Krause, M, Benezra, R, Blackwell, TK, Turner, D, Rupp, R, Hollenberg, S, Zhuang, Y & Lassar, A 1991, 'The myoD gene family: Nodal point during specification of the muscle cell lineage', Science, vol. 251, no. 4995, pp. 761-766.
Weintraub H, Davis R, Tapscott S, Thayer MM, Krause M, Benezra R et al. The myoD gene family: Nodal point during specification of the muscle cell lineage. Science. 1991 Feb 15;251(4995):761-766.
Weintraub, Harold ; Davis, Robert ; Tapscott, Stephen ; Thayer, Mathew (Matt) ; Krause, Michael ; Benezra, Robert ; Blackwell, T. Keith ; Turner, David ; Rupp, Ralph ; Hollenberg, Stanley ; Zhuang, Yuan ; Lassar, Andrew. / The myoD gene family : Nodal point during specification of the muscle cell lineage. In: Science. 1991 ; Vol. 251, No. 4995. pp. 761-766.
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