The mutacins of Streptococcus mutans: Regulation and ecology

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Streptococcus mutans is generally recognized as a causative agent of human dental caries. The production of mutacins (bacteriocins) by S. mutans is considered to be an important factor in the colonization and establishment of S. mutans in the dental biofilm. Two types of mutacins have been characterized: the lantibiotics and the non-lantibiotics. The lantibiotics generally have a wider spectrum of activity than the non-lantibiotics, which make them attractive targets for development into new antimicrobial modalities. The non-lantibiotics are much more prevalent among strains of S. mutans and play a significant role in both community-level and population-level interactions in the dental biofilm. These interactions are directly mediated through the ComCDE two-component system and the newly characterized LytTR Regulation Systems HdrRM and BrsRM. These systems coordinate natural competence development and mutacin production as a means to acquire transforming DNA either by killing closely related streptococcal species in the vicinity of S. mutans, or through an altruistic suicide mechanism among a subpopulation of competent cells within the S. mutans community. As more S. mutans strains are sequenced, it is anticipated that additional mutacins with novel functions will be discovered, which may yield further insights into the ecological role of mutacins within the oral biofilm.

Original languageEnglish (US)
Pages (from-to)57-69
Number of pages13
JournalMolecular Oral Microbiology
Volume27
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Streptococcus mutans
Ecology
Bacteriocins
Biofilms
Tooth
Dental Caries
Mental Competency
Suicide
DNA
Population

Keywords

  • Bacteriocin
  • Mutacin
  • Streptococcus mutans

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Microbiology (medical)
  • Dentistry(all)

Cite this

The mutacins of Streptococcus mutans : Regulation and ecology. / Merritt, Justin; Qi, F.

In: Molecular Oral Microbiology, Vol. 27, No. 2, 04.2012, p. 57-69.

Research output: Contribution to journalArticle

@article{ee7ac0f54d894d51a8b1b8b296b5e6d6,
title = "The mutacins of Streptococcus mutans: Regulation and ecology",
abstract = "Streptococcus mutans is generally recognized as a causative agent of human dental caries. The production of mutacins (bacteriocins) by S. mutans is considered to be an important factor in the colonization and establishment of S. mutans in the dental biofilm. Two types of mutacins have been characterized: the lantibiotics and the non-lantibiotics. The lantibiotics generally have a wider spectrum of activity than the non-lantibiotics, which make them attractive targets for development into new antimicrobial modalities. The non-lantibiotics are much more prevalent among strains of S. mutans and play a significant role in both community-level and population-level interactions in the dental biofilm. These interactions are directly mediated through the ComCDE two-component system and the newly characterized LytTR Regulation Systems HdrRM and BrsRM. These systems coordinate natural competence development and mutacin production as a means to acquire transforming DNA either by killing closely related streptococcal species in the vicinity of S. mutans, or through an altruistic suicide mechanism among a subpopulation of competent cells within the S. mutans community. As more S. mutans strains are sequenced, it is anticipated that additional mutacins with novel functions will be discovered, which may yield further insights into the ecological role of mutacins within the oral biofilm.",
keywords = "Bacteriocin, Mutacin, Streptococcus mutans",
author = "Justin Merritt and F. Qi",
year = "2012",
month = "4",
doi = "10.1111/j.2041-1014.2011.00634.x",
language = "English (US)",
volume = "27",
pages = "57--69",
journal = "Molecular Oral Microbiology",
issn = "2041-1006",
publisher = "American Journal of Nursing Company",
number = "2",

}

TY - JOUR

T1 - The mutacins of Streptococcus mutans

T2 - Regulation and ecology

AU - Merritt, Justin

AU - Qi, F.

PY - 2012/4

Y1 - 2012/4

N2 - Streptococcus mutans is generally recognized as a causative agent of human dental caries. The production of mutacins (bacteriocins) by S. mutans is considered to be an important factor in the colonization and establishment of S. mutans in the dental biofilm. Two types of mutacins have been characterized: the lantibiotics and the non-lantibiotics. The lantibiotics generally have a wider spectrum of activity than the non-lantibiotics, which make them attractive targets for development into new antimicrobial modalities. The non-lantibiotics are much more prevalent among strains of S. mutans and play a significant role in both community-level and population-level interactions in the dental biofilm. These interactions are directly mediated through the ComCDE two-component system and the newly characterized LytTR Regulation Systems HdrRM and BrsRM. These systems coordinate natural competence development and mutacin production as a means to acquire transforming DNA either by killing closely related streptococcal species in the vicinity of S. mutans, or through an altruistic suicide mechanism among a subpopulation of competent cells within the S. mutans community. As more S. mutans strains are sequenced, it is anticipated that additional mutacins with novel functions will be discovered, which may yield further insights into the ecological role of mutacins within the oral biofilm.

AB - Streptococcus mutans is generally recognized as a causative agent of human dental caries. The production of mutacins (bacteriocins) by S. mutans is considered to be an important factor in the colonization and establishment of S. mutans in the dental biofilm. Two types of mutacins have been characterized: the lantibiotics and the non-lantibiotics. The lantibiotics generally have a wider spectrum of activity than the non-lantibiotics, which make them attractive targets for development into new antimicrobial modalities. The non-lantibiotics are much more prevalent among strains of S. mutans and play a significant role in both community-level and population-level interactions in the dental biofilm. These interactions are directly mediated through the ComCDE two-component system and the newly characterized LytTR Regulation Systems HdrRM and BrsRM. These systems coordinate natural competence development and mutacin production as a means to acquire transforming DNA either by killing closely related streptococcal species in the vicinity of S. mutans, or through an altruistic suicide mechanism among a subpopulation of competent cells within the S. mutans community. As more S. mutans strains are sequenced, it is anticipated that additional mutacins with novel functions will be discovered, which may yield further insights into the ecological role of mutacins within the oral biofilm.

KW - Bacteriocin

KW - Mutacin

KW - Streptococcus mutans

UR - http://www.scopus.com/inward/record.url?scp=84858049821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858049821&partnerID=8YFLogxK

U2 - 10.1111/j.2041-1014.2011.00634.x

DO - 10.1111/j.2041-1014.2011.00634.x

M3 - Article

C2 - 22394465

AN - SCOPUS:84858049821

VL - 27

SP - 57

EP - 69

JO - Molecular Oral Microbiology

JF - Molecular Oral Microbiology

SN - 2041-1006

IS - 2

ER -