The Mullerian inhibiting substance gene is transcribed in human ovarian carcinomas with and without 19p rearrangements

P. Aman, T. Pejovic, S. Heim, F. Mitelman

Research output: Contribution to journalArticle

Abstract

The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalInternational Journal of Oncology
Volume5
Issue number2
DOIs
StatePublished - 1994

Keywords

  • Mullerian inhibiting substance
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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