The Mullerian inhibiting substance gene is transcribed in human ovarian carcinomas with and without 19p rearrangements

P. Aman, Tanja Pejovic, S. Heim, F. Mitelman

Research output: Contribution to journalArticle

Abstract

The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalInternational Journal of Oncology
Volume5
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Anti-Mullerian Hormone
Carcinoma
Genes
Loss of Heterozygosity
Tumor Suppressor Genes
Chromosome Aberrations
Ovarian Neoplasms
Neoplasms
Chromosomes
Cell Line

Keywords

  • Mullerian inhibiting substance
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The Mullerian inhibiting substance gene is transcribed in human ovarian carcinomas with and without 19p rearrangements. / Aman, P.; Pejovic, Tanja; Heim, S.; Mitelman, F.

In: International Journal of Oncology, Vol. 5, No. 2, 1994, p. 177-179.

Research output: Contribution to journalArticle

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