The Mullerian inhibiting substance gene is transcribed in human ovarian carcinomas with and without 19p rearrangements

P. Aman; T. Pejovic; S. Heim; F. Mitelman

doi:10.3892/ijo.5.2.177

The Mullerian inhibiting substance gene is transcribed in human ovarian carcinomas with and without 19p rearrangements

P. Aman, T. Pejovic, S. Heim, F. Mitelman

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.

Original language	English (US)
Pages (from-to)	177-179
Number of pages	3
Journal	International Journal of Oncology
Volume	5
Issue number	2
DOIs	https://doi.org/10.3892/ijo.5.2.177
State	Published - 1994
Externally published	Yes

Keywords

Mullerian inhibiting substance
Ovarian carcinoma

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3892/ijo.5.2.177

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abstract = "The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.",

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AU - Aman, P.

AU - Pejovic, T.

AU - Heim, S.

AU - Mitelman, F.

PY - 1994

Y1 - 1994

N2 - The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.

AB - The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.

KW - Mullerian inhibiting substance

KW - Ovarian carcinoma

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The Mullerian inhibiting substance gene is transcribed in human ovarian carcinomas with and without 19p rearrangements

Abstract

Keywords

ASJC Scopus subject areas

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