The Mullerian inhibiting substance (MIS) is a factor which inhibits proliferation in some ovarian carcinoma cell lines. The MIS encoding gene, AMH, is located in chromosome sub-band 19p13.3. One third of human ovarian carcinomas show loss of heterozygosity for DNA sequences in 19p and half of the cases with clonal chromosome aberrations have abnormalities affecting 19p13. AMH might therefore be the putative tumor suppressor gene that is lost or inactivated in ovarian cancer. However, we found a normal-sized AMH transcript in 11 of 12 investigated tumors as well as in normal ovarian tissue. This indicates that MIS is not a functionally important suppressor substance in these tumors.
- Mullerian inhibiting substance
- Ovarian carcinoma
ASJC Scopus subject areas
- Cancer Research