The molecular logic of sodium-coupled neurotransmitter transporters

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Synaptic transmission at chemical synapses requires the removal of neurotransmitter from extracellular spaces. At synapses in the central nervous system, this is accomplished by sodium-coupled transport proteins, integral membrane proteins that thermodynamically couple the uptake of neurotransmitter to the uptake of sodium and, in some cases, the uptake and export of additional ions. Recent X-ray crystallographic studies have revealed the architecture of the two major families of neurotransmitter transporters and, together with additional biochemical and biophysical studies, have provided insights into mechanisms of ion coupling, substrate uptake, and inhibition of transport.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume364
Issue number1514
DOIs
StatePublished - 2009

Keywords

  • Chemical synapses
  • Crystallography
  • Neurotransmitters
  • Sodium-coupled transporters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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