TY - JOUR
T1 - The mitochondrial permeability transition pore
T2 - Channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
AU - Bernardi, Paolo
AU - Rasola, Andrea
AU - Forte, Michael
AU - Lippe, Giovanna
N1 - Publisher Copyright:
© 2015 the American Physiological Society.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of putative protein components that have been tested by genetic analysis. The discovery that under conditions of oxidative stress the F-ATP synthases of mammals, yeast, and Drosophila can be turned into Ca2+-dependent channels, whose electrophysiological properties match those of the corresponding PTPs, opens new perspectives to the field. We discuss structural and functional features of F-ATP synthases that may provide clues to its transition from an energy-conserving into an energy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
AB - The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of putative protein components that have been tested by genetic analysis. The discovery that under conditions of oxidative stress the F-ATP synthases of mammals, yeast, and Drosophila can be turned into Ca2+-dependent channels, whose electrophysiological properties match those of the corresponding PTPs, opens new perspectives to the field. We discuss structural and functional features of F-ATP synthases that may provide clues to its transition from an energy-conserving into an energy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
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U2 - 10.1152/physrev.00001.2015
DO - 10.1152/physrev.00001.2015
M3 - Article
C2 - 26269524
AN - SCOPUS:84939248947
SN - 0031-9333
VL - 95
SP - 1111
EP - 1155
JO - Physiological Reviews
JF - Physiological Reviews
IS - 4
ER -