The Mitochondrial Permeability Transition Pore

Paolo Bernardi, Michael Forte

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The mitochondrial permeability transition pore (PTP) is a high conductance channel of the inner membrane whose opening leads to an increase of permeability to solutes with molecular masses up to about 1500 Da, the 'permeability transition'. This potentially catastrophic event has long been known, yet the molecular bases for its occurrence remain unsolved despite its established importance in several in vivo models of pathology. Recent studies based on inactivation of genes encoding putative pore components (such as the adenine nucleotide translocators and the voltage-dependent anion channel) have raised major questions about the involvement of these proteins in PTP formation, yet they have conclusively demonstrated the role of matrix cyclophilin D as the mitochondrial receptor for the desensitizing effects of cyclosporin A. While the nature of the components forming the PTP remains controversial, the identification of novel inhibitors that can be used as affinity labels is offering new perspectives towards the molecular definition of the PTP.

Original languageEnglish (US)
Title of host publicationMitochondrial Biology
Subtitle of host publicationNew Perspectives
Publisherwiley
Pages157-164
Number of pages8
ISBN (Electronic)9780470725207
ISBN (Print)9780470066577
DOIs
StatePublished - May 20 2008

Keywords

  • Outer mitochondrial membrane
  • Patch clamp analysis
  • Permeability transition pore
  • Pore molecular structure
  • Protein-protein interactions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Bernardi, P., & Forte, M. (2008). The Mitochondrial Permeability Transition Pore. In Mitochondrial Biology: New Perspectives (pp. 157-164). wiley. https://doi.org/10.1002/9780470725207.ch11