The mitochondrial permeability transition from yeast to mammals

Luca Azzolin, Sophia von Stockum, Emy Basso, Valeria Petronilli, Michael Forte, Paolo Bernardi

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Regulated permeability changes have been detected in mitochondria across species. We review here their key features, with the goal of assessing whether a " permeability transition" similar to that observed in higher eukaryotes is present in other species. The recent discoveries (i) that treatment with cyclosporin A (CsA) unmasks an inhibitory site for inorganic phosphate (Pi) [Basso, E., Petronilli, V., Forte, M.A. and Bernardi, P. (2008) Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J. Biol. Chem. 283, 26307-26311], the classical inhibitor of the permeability transition of yeast and (ii) that under proper experimental conditions a matrix Ca2+-dependence can be demonstrated in yeast as well [Yamada, A., Yamamoto, T., Yoshimura, Y., Gouda, S., Kawashima, S., Yamazaki, N., Yamashita, K., Kataoka, M., Nagata, T., Terada, H., Pfeiffer, D.R. and Shinohara Y. (2009) Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions. Biochim. Biophys. Acta 1787, 1486-1491] suggest that the mitochondrial permeability transition has been conserved during evolution.

Original languageEnglish (US)
Pages (from-to)2504-2509
Number of pages6
JournalFEBS Letters
Volume584
Issue number12
DOIs
StatePublished - Jun 2010

Fingerprint

Mammals
Yeast
Permeability
Mitochondria
Yeasts
Cyclosporine
Phosphates
Ablation
Eukaryota

Keywords

  • Calcium
  • Cyclophilin
  • Cyclosporin
  • Mitochondria
  • Permeability transition

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Azzolin, L., von Stockum, S., Basso, E., Petronilli, V., Forte, M., & Bernardi, P. (2010). The mitochondrial permeability transition from yeast to mammals. FEBS Letters, 584(12), 2504-2509. https://doi.org/10.1016/j.febslet.2010.04.023

The mitochondrial permeability transition from yeast to mammals. / Azzolin, Luca; von Stockum, Sophia; Basso, Emy; Petronilli, Valeria; Forte, Michael; Bernardi, Paolo.

In: FEBS Letters, Vol. 584, No. 12, 06.2010, p. 2504-2509.

Research output: Contribution to journalArticle

Azzolin, L, von Stockum, S, Basso, E, Petronilli, V, Forte, M & Bernardi, P 2010, 'The mitochondrial permeability transition from yeast to mammals', FEBS Letters, vol. 584, no. 12, pp. 2504-2509. https://doi.org/10.1016/j.febslet.2010.04.023
Azzolin L, von Stockum S, Basso E, Petronilli V, Forte M, Bernardi P. The mitochondrial permeability transition from yeast to mammals. FEBS Letters. 2010 Jun;584(12):2504-2509. https://doi.org/10.1016/j.febslet.2010.04.023
Azzolin, Luca ; von Stockum, Sophia ; Basso, Emy ; Petronilli, Valeria ; Forte, Michael ; Bernardi, Paolo. / The mitochondrial permeability transition from yeast to mammals. In: FEBS Letters. 2010 ; Vol. 584, No. 12. pp. 2504-2509.
@article{8e7798af514242828cc38e6f4a9b7f62,
title = "The mitochondrial permeability transition from yeast to mammals",
abstract = "Regulated permeability changes have been detected in mitochondria across species. We review here their key features, with the goal of assessing whether a {"} permeability transition{"} similar to that observed in higher eukaryotes is present in other species. The recent discoveries (i) that treatment with cyclosporin A (CsA) unmasks an inhibitory site for inorganic phosphate (Pi) [Basso, E., Petronilli, V., Forte, M.A. and Bernardi, P. (2008) Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J. Biol. Chem. 283, 26307-26311], the classical inhibitor of the permeability transition of yeast and (ii) that under proper experimental conditions a matrix Ca2+-dependence can be demonstrated in yeast as well [Yamada, A., Yamamoto, T., Yoshimura, Y., Gouda, S., Kawashima, S., Yamazaki, N., Yamashita, K., Kataoka, M., Nagata, T., Terada, H., Pfeiffer, D.R. and Shinohara Y. (2009) Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions. Biochim. Biophys. Acta 1787, 1486-1491] suggest that the mitochondrial permeability transition has been conserved during evolution.",
keywords = "Calcium, Cyclophilin, Cyclosporin, Mitochondria, Permeability transition",
author = "Luca Azzolin and {von Stockum}, Sophia and Emy Basso and Valeria Petronilli and Michael Forte and Paolo Bernardi",
year = "2010",
month = "6",
doi = "10.1016/j.febslet.2010.04.023",
language = "English (US)",
volume = "584",
pages = "2504--2509",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "12",

}

TY - JOUR

T1 - The mitochondrial permeability transition from yeast to mammals

AU - Azzolin, Luca

AU - von Stockum, Sophia

AU - Basso, Emy

AU - Petronilli, Valeria

AU - Forte, Michael

AU - Bernardi, Paolo

PY - 2010/6

Y1 - 2010/6

N2 - Regulated permeability changes have been detected in mitochondria across species. We review here their key features, with the goal of assessing whether a " permeability transition" similar to that observed in higher eukaryotes is present in other species. The recent discoveries (i) that treatment with cyclosporin A (CsA) unmasks an inhibitory site for inorganic phosphate (Pi) [Basso, E., Petronilli, V., Forte, M.A. and Bernardi, P. (2008) Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J. Biol. Chem. 283, 26307-26311], the classical inhibitor of the permeability transition of yeast and (ii) that under proper experimental conditions a matrix Ca2+-dependence can be demonstrated in yeast as well [Yamada, A., Yamamoto, T., Yoshimura, Y., Gouda, S., Kawashima, S., Yamazaki, N., Yamashita, K., Kataoka, M., Nagata, T., Terada, H., Pfeiffer, D.R. and Shinohara Y. (2009) Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions. Biochim. Biophys. Acta 1787, 1486-1491] suggest that the mitochondrial permeability transition has been conserved during evolution.

AB - Regulated permeability changes have been detected in mitochondria across species. We review here their key features, with the goal of assessing whether a " permeability transition" similar to that observed in higher eukaryotes is present in other species. The recent discoveries (i) that treatment with cyclosporin A (CsA) unmasks an inhibitory site for inorganic phosphate (Pi) [Basso, E., Petronilli, V., Forte, M.A. and Bernardi, P. (2008) Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J. Biol. Chem. 283, 26307-26311], the classical inhibitor of the permeability transition of yeast and (ii) that under proper experimental conditions a matrix Ca2+-dependence can be demonstrated in yeast as well [Yamada, A., Yamamoto, T., Yoshimura, Y., Gouda, S., Kawashima, S., Yamazaki, N., Yamashita, K., Kataoka, M., Nagata, T., Terada, H., Pfeiffer, D.R. and Shinohara Y. (2009) Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions. Biochim. Biophys. Acta 1787, 1486-1491] suggest that the mitochondrial permeability transition has been conserved during evolution.

KW - Calcium

KW - Cyclophilin

KW - Cyclosporin

KW - Mitochondria

KW - Permeability transition

UR - http://www.scopus.com/inward/record.url?scp=77953131418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953131418&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2010.04.023

DO - 10.1016/j.febslet.2010.04.023

M3 - Article

C2 - 20398660

AN - SCOPUS:77953131418

VL - 584

SP - 2504

EP - 2509

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 12

ER -