The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine

Dane Dickson, Jennifer Johnson, Raymond Bergan, Rebecca Owens, Vivek Subbiah, Razelle Kurzrock

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalCell
Volume180
Issue number1
DOIs
StatePublished - Jan 9 2020

Keywords

  • ROOT
  • evidence
  • innovation
  • innovation
  • master
  • protocol
  • quality
  • real-world data
  • trial

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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