The many faces of B Cells: From generation of antibodies to immune regulation

Robert Schelonka, Akhil Maheshwari

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Abstract

B lineage lymphocytes (B cells) produce exquisitely specific and long-lasting antibodies that recognize a broad and ever-changing array of foreign antigens and microbial pathogens. Perturbations in B-cell development maturation lead to specific immune disturbances. Certain features intrinsic to fetal and neonatal B cells contribute to what has been called the relative immunodeficiency of infancy. Although the primary function of B lineage cells is to produce antibodies for host defense, emerging data show that B cells are key activators and regulators of the immune response.

Original languageEnglish (US)
JournalNeoReviews
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 1 2013

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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