The management of carcinoma of the anal canal by external beam radiotherapy, experience in Vancouver 1971-1988

G. Newman, D. C. Calverley, B. D. Acker, M. Manji, J. Haya, A. D. Flores

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    From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiotherapy, most commonly by 5000 cGy in 20 fractions given over 4 weeks. The actuarial survival at 5 years was 66% and the disease specific survival 78%. Nine patients had inguinal node metastases at diagnosis; their 5-year disease specific survival was 75%. 63 patients were inguinal node negative at presentation; their 5-year disease specific survival was 78%, by UICC 1987 staging: T1 71%, T2 88%, T3 41%, T442%. 17 patients developed local recurrence; 10 were suitable for abdominoperineal (AP) resection which was successful in 7. The probability of local control was related to T stage. 13 patients were left with a colostomy because of recurrence, 2 had a colostomy for radiation damage and 4 had their local recurrence managed palliatively, without a colostomy. As a result, 53 of the 72 patients (74%) were left with a functional anus. Severe late complications occurred in 6 (8%).

    Original languageEnglish (US)
    Pages (from-to)196-202
    Number of pages7
    JournalRadiotherapy and Oncology
    Issue number3
    StatePublished - Nov 1992



    • Anal canal
    • Carcinoma
    • Clinical experience
    • External beam radiotherapy

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Radiology Nuclear Medicine and imaging

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