The management of carcinoma of the anal canal by external beam radiotherapy, experience in Vancouver 1971-1988

G. Newman, D. C. Calverley, B. D. Acker, M. Manji, J. Haya, A. D. Flores

    Research output: Contribution to journalArticle

    33 Scopus citations

    Abstract

    From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiotherapy, most commonly by 5000 cGy in 20 fractions given over 4 weeks. The actuarial survival at 5 years was 66% and the disease specific survival 78%. Nine patients had inguinal node metastases at diagnosis; their 5-year disease specific survival was 75%. 63 patients were inguinal node negative at presentation; their 5-year disease specific survival was 78%, by UICC 1987 staging: T1 71%, T2 88%, T3 41%, T442%. 17 patients developed local recurrence; 10 were suitable for abdominoperineal (AP) resection which was successful in 7. The probability of local control was related to T stage. 13 patients were left with a colostomy because of recurrence, 2 had a colostomy for radiation damage and 4 had their local recurrence managed palliatively, without a colostomy. As a result, 53 of the 72 patients (74%) were left with a functional anus. Severe late complications occurred in 6 (8%).

    Original languageEnglish (US)
    Pages (from-to)196-202
    Number of pages7
    JournalRadiotherapy and Oncology
    Volume25
    Issue number3
    DOIs
    StatePublished - Nov 1992

      Fingerprint

    Keywords

    • Anal canal
    • Carcinoma
    • Clinical experience
    • External beam radiotherapy

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Radiology Nuclear Medicine and imaging

    Cite this