Abstract
From 1971 to 1988 72 cases of carcinoma of the anal canal were treated by external beam radiotherapy, most commonly by 5000 cGy in 20 fractions given over 4 weeks. The actuarial survival at 5 years was 66% and the disease specific survival 78%. Nine patients had inguinal node metastases at diagnosis; their 5-year disease specific survival was 75%. 63 patients were inguinal node negative at presentation; their 5-year disease specific survival was 78%, by UICC 1987 staging: T1 71%, T2 88%, T3 41%, T442%. 17 patients developed local recurrence; 10 were suitable for abdominoperineal (AP) resection which was successful in 7. The probability of local control was related to T stage. 13 patients were left with a colostomy because of recurrence, 2 had a colostomy for radiation damage and 4 had their local recurrence managed palliatively, without a colostomy. As a result, 53 of the 72 patients (74%) were left with a functional anus. Severe late complications occurred in 6 (8%).
Original language | English (US) |
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Pages (from-to) | 196-202 |
Number of pages | 7 |
Journal | Radiotherapy and Oncology |
Volume | 25 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1992 |
Externally published | Yes |
Keywords
- Anal canal
- Carcinoma
- Clinical experience
- External beam radiotherapy
ASJC Scopus subject areas
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging