The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages

Lara Vojnov, Mauricio A. Martins, Alexander T. Bean, Marlon G.Veloso de Santana, Jonah B. Sacha, Nancy A. Wilson, Myrna C. Bonaldo, Ricardo Galler, Mario Stevenson, David I. Watkins

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to produce virus over long periods of time.

Original languageEnglish (US)
Pages (from-to)4682-4687
Number of pages6
JournalJournal of virology
Volume86
Issue number8
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Vojnov, L., Martins, M. A., Bean, A. T., de Santana, M. G. V., Sacha, J. B., Wilson, N. A., Bonaldo, M. C., Galler, R., Stevenson, M., & Watkins, D. I. (2012). The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages. Journal of virology, 86(8), 4682-4687. https://doi.org/10.1128/JVI.06324-11