The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages

Lara Vojnov; Mauricio A. Martins; Alexander T. Bean; Marlon G.Veloso de Santana; Jonah B. Sacha; Nancy A. Wilson; Myrna C. Bonaldo; Ricardo Galler; Mario Stevenson; David I. Watkins

doi:10.1128/JVI.06324-11

The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8⁺ T cells cannot suppress viral replication in SIV-infected macrophages

Lara Vojnov, Mauricio A. Martins, Alexander T. Bean, Marlon G.Veloso de Santana, Jonah B. Sacha, Nancy A. Wilson, Myrna C. Bonaldo, Ricardo Galler, Mario Stevenson, David I. Watkins

Oregon National Primate Research Center

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4⁺ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8⁺ T cells that eliminated and suppressed viral replication in SIV-infected CD4⁺ T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8⁺ T cell-mediated lysis and continue to produce virus over long periods of time.

Original language	English (US)
Pages (from-to)	4682-4687
Number of pages	6
Journal	Journal of virology
Volume	86
Issue number	8
DOIs	https://doi.org/10.1128/JVI.06324-11
State	Published - Apr 2012

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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Vojnov, L., Martins, M. A., Bean, A. T., de Santana, M. G. V., Sacha, J. B., Wilson, N. A., Bonaldo, M. C., Galler, R., Stevenson, M., & Watkins, D. I. (2012). The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8⁺ T cells cannot suppress viral replication in SIV-infected macrophages. Journal of virology, 86(8), 4682-4687. https://doi.org/10.1128/JVI.06324-11

Vojnov, L, Martins, MA, Bean, AT, de Santana, MGV, Sacha, JB, Wilson, NA, Bonaldo, MC, Galler, R, Stevenson, M & Watkins, DI 2012, 'The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8⁺ T cells cannot suppress viral replication in SIV-infected macrophages', Journal of virology, vol. 86, no. 8, pp. 4682-4687. https://doi.org/10.1128/JVI.06324-11

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abstract = "Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to produce virus over long periods of time.",

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AU - Bean, Alexander T.

AU - de Santana, Marlon G.Veloso

AU - Sacha, Jonah B.

AU - Wilson, Nancy A.

AU - Bonaldo, Myrna C.

AU - Galler, Ricardo

AU - Stevenson, Mario

AU - Watkins, David I.

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AB - Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to produce virus over long periods of time.

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The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8⁺ T cells cannot suppress viral replication in SIV-infected macrophages

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