The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages

Lara Vojnov, Mauricio A. Martins, Alexander T. Bean, Marlon G Veloso de Santana, Jonah Sacha, Nancy A. Wilson, Myrna C. Bonaldo, Ricardo Galler, Mario Stevenson, David I. Watkins

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to produce virus over long periods of time.

Original languageEnglish (US)
Pages (from-to)4682-4687
Number of pages6
JournalJournal of Virology
Volume86
Issue number8
DOIs
StatePublished - Apr 2012

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
virus replication
macrophages
T-lymphocytes
Macrophages
T-Lymphocytes
viruses
HIV
Viruses
Human immunodeficiency virus
cells

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages. / Vojnov, Lara; Martins, Mauricio A.; Bean, Alexander T.; de Santana, Marlon G Veloso; Sacha, Jonah; Wilson, Nancy A.; Bonaldo, Myrna C.; Galler, Ricardo; Stevenson, Mario; Watkins, David I.

In: Journal of Virology, Vol. 86, No. 8, 04.2012, p. 4682-4687.

Research output: Contribution to journalArticle

Vojnov, L, Martins, MA, Bean, AT, de Santana, MGV, Sacha, J, Wilson, NA, Bonaldo, MC, Galler, R, Stevenson, M & Watkins, DI 2012, 'The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages', Journal of Virology, vol. 86, no. 8, pp. 4682-4687. https://doi.org/10.1128/JVI.06324-11
Vojnov, Lara ; Martins, Mauricio A. ; Bean, Alexander T. ; de Santana, Marlon G Veloso ; Sacha, Jonah ; Wilson, Nancy A. ; Bonaldo, Myrna C. ; Galler, Ricardo ; Stevenson, Mario ; Watkins, David I. / The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages. In: Journal of Virology. 2012 ; Vol. 86, No. 8. pp. 4682-4687.
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