The Lyt phenotype of cells involved in the cytotoxic response to syngeneic tumor and of tumor-specific suppressor cells

T. Maier, J. G. Levy, D. G. Kilburn

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Suppressor cells, which specifically suppress the in vitro response of syngeneic spleen cells to the DBA/2 mastocytoma, P815, were identified in the spleens of DBA/2 mice injected intraperitoneally with membrane extracts of the P815 tumor. The Lyt phenotypes of various effector cells were determined. DBA/2 allogeneic killer cells were identified as Lyt-12+, whereas the syngeneic effector cells were found to be predominantly Lyt-2+. The suppressor cell population lost its ability to suppress the in vitro cytotoxic anti-P815 response after treatment with anti-Lyt-1 serum plus complement but not after treatment with anti-Lyt-2 serum, indicating that an Lyt-1+ cell is essential in this suppression.

Original languageEnglish (US)
Pages (from-to)392-399
Number of pages8
JournalCellular Immunology
Volume56
Issue number2
DOIs
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Immunology

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