The long-term effects of nefiracetam on learning in older rabbits

Diana S. Woodruff-Pak, John T. Green, Jonathan Pak, Tadashi Shiotani, Shigeo Watabe, Makoto Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Classical conditioning of the nictitating membrane (NM)/eyeblink response has proven utility in the study of age-related memory disorders. The 750 ms delay eyeblink conditioning procedure was used to investigate the magnitude and duration of the nootropic drug nefiracetam's effect on retention and relearning. After administering daily injections of 0 (vehicle), 5, 10, or 15 mg/kg nefiracetam to 34 retired breeder rabbits during 15 days of acquisition, we tested retention and relearning 1, 5, and 12 weeks post-training. Rabbits received no drug after the initial 15 daily injections. Significant relearning was observed in the 10 mg/kg nefiracetam group 1 and 5 weeks after initial acquisition. Differences in tone-alone retention did not achieve statistical significance, although responses were numerically greater in the 10 mg/kg nefiracetam group. The effect of nefiracetam upon the ability of older rabbits to relearn a previously learned task is apparent up to 5 weeks after drug administration. Under normal conditions, a drug is administered continuously. In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration.

Original languageEnglish (US)
Pages (from-to)299-308
Number of pages10
JournalBehavioural Brain Research
Volume136
Issue number1
DOIs
StatePublished - Oct 17 2002
Externally publishedYes

Fingerprint

Learning
Rabbits
Pharmaceutical Preparations
Nictitating Membrane
Nootropic Agents
Injections
Aptitude
Classical Conditioning
Memory Disorders
nefiracetam
Retention (Psychology)

Keywords

  • Aging
  • Alzheimer's disease
  • Cognition-enhancing drug
  • Eyeblink classical conditioning
  • Hippocampus
  • Nicotinic acetylcholine receptors
  • Relearning
  • Retention

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Woodruff-Pak, D. S., Green, J. T., Pak, J., Shiotani, T., Watabe, S., & Tanaka, M. (2002). The long-term effects of nefiracetam on learning in older rabbits. Behavioural Brain Research, 136(1), 299-308. https://doi.org/10.1016/S0166-4328(02)00186-9

The long-term effects of nefiracetam on learning in older rabbits. / Woodruff-Pak, Diana S.; Green, John T.; Pak, Jonathan; Shiotani, Tadashi; Watabe, Shigeo; Tanaka, Makoto.

In: Behavioural Brain Research, Vol. 136, No. 1, 17.10.2002, p. 299-308.

Research output: Contribution to journalArticle

Woodruff-Pak, DS, Green, JT, Pak, J, Shiotani, T, Watabe, S & Tanaka, M 2002, 'The long-term effects of nefiracetam on learning in older rabbits', Behavioural Brain Research, vol. 136, no. 1, pp. 299-308. https://doi.org/10.1016/S0166-4328(02)00186-9
Woodruff-Pak, Diana S. ; Green, John T. ; Pak, Jonathan ; Shiotani, Tadashi ; Watabe, Shigeo ; Tanaka, Makoto. / The long-term effects of nefiracetam on learning in older rabbits. In: Behavioural Brain Research. 2002 ; Vol. 136, No. 1. pp. 299-308.
@article{d1eed32b2de94c1ea57fd05fc26a4548,
title = "The long-term effects of nefiracetam on learning in older rabbits",
abstract = "Classical conditioning of the nictitating membrane (NM)/eyeblink response has proven utility in the study of age-related memory disorders. The 750 ms delay eyeblink conditioning procedure was used to investigate the magnitude and duration of the nootropic drug nefiracetam's effect on retention and relearning. After administering daily injections of 0 (vehicle), 5, 10, or 15 mg/kg nefiracetam to 34 retired breeder rabbits during 15 days of acquisition, we tested retention and relearning 1, 5, and 12 weeks post-training. Rabbits received no drug after the initial 15 daily injections. Significant relearning was observed in the 10 mg/kg nefiracetam group 1 and 5 weeks after initial acquisition. Differences in tone-alone retention did not achieve statistical significance, although responses were numerically greater in the 10 mg/kg nefiracetam group. The effect of nefiracetam upon the ability of older rabbits to relearn a previously learned task is apparent up to 5 weeks after drug administration. Under normal conditions, a drug is administered continuously. In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration.",
keywords = "Aging, Alzheimer's disease, Cognition-enhancing drug, Eyeblink classical conditioning, Hippocampus, Nicotinic acetylcholine receptors, Relearning, Retention",
author = "Woodruff-Pak, {Diana S.} and Green, {John T.} and Jonathan Pak and Tadashi Shiotani and Shigeo Watabe and Makoto Tanaka",
year = "2002",
month = "10",
day = "17",
doi = "10.1016/S0166-4328(02)00186-9",
language = "English (US)",
volume = "136",
pages = "299--308",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The long-term effects of nefiracetam on learning in older rabbits

AU - Woodruff-Pak, Diana S.

AU - Green, John T.

AU - Pak, Jonathan

AU - Shiotani, Tadashi

AU - Watabe, Shigeo

AU - Tanaka, Makoto

PY - 2002/10/17

Y1 - 2002/10/17

N2 - Classical conditioning of the nictitating membrane (NM)/eyeblink response has proven utility in the study of age-related memory disorders. The 750 ms delay eyeblink conditioning procedure was used to investigate the magnitude and duration of the nootropic drug nefiracetam's effect on retention and relearning. After administering daily injections of 0 (vehicle), 5, 10, or 15 mg/kg nefiracetam to 34 retired breeder rabbits during 15 days of acquisition, we tested retention and relearning 1, 5, and 12 weeks post-training. Rabbits received no drug after the initial 15 daily injections. Significant relearning was observed in the 10 mg/kg nefiracetam group 1 and 5 weeks after initial acquisition. Differences in tone-alone retention did not achieve statistical significance, although responses were numerically greater in the 10 mg/kg nefiracetam group. The effect of nefiracetam upon the ability of older rabbits to relearn a previously learned task is apparent up to 5 weeks after drug administration. Under normal conditions, a drug is administered continuously. In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration.

AB - Classical conditioning of the nictitating membrane (NM)/eyeblink response has proven utility in the study of age-related memory disorders. The 750 ms delay eyeblink conditioning procedure was used to investigate the magnitude and duration of the nootropic drug nefiracetam's effect on retention and relearning. After administering daily injections of 0 (vehicle), 5, 10, or 15 mg/kg nefiracetam to 34 retired breeder rabbits during 15 days of acquisition, we tested retention and relearning 1, 5, and 12 weeks post-training. Rabbits received no drug after the initial 15 daily injections. Significant relearning was observed in the 10 mg/kg nefiracetam group 1 and 5 weeks after initial acquisition. Differences in tone-alone retention did not achieve statistical significance, although responses were numerically greater in the 10 mg/kg nefiracetam group. The effect of nefiracetam upon the ability of older rabbits to relearn a previously learned task is apparent up to 5 weeks after drug administration. Under normal conditions, a drug is administered continuously. In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration.

KW - Aging

KW - Alzheimer's disease

KW - Cognition-enhancing drug

KW - Eyeblink classical conditioning

KW - Hippocampus

KW - Nicotinic acetylcholine receptors

KW - Relearning

KW - Retention

UR - http://www.scopus.com/inward/record.url?scp=0037126174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037126174&partnerID=8YFLogxK

U2 - 10.1016/S0166-4328(02)00186-9

DO - 10.1016/S0166-4328(02)00186-9

M3 - Article

C2 - 12385816

AN - SCOPUS:0037126174

VL - 136

SP - 299

EP - 308

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -