The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni

Mark Zabriskie, Chris M. Ireland

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Two cytotoxic pyrrolo[2,3-d]pyrimidine nucleosides, toyocamycin [2] and 5-(methoxycarbonyl)tubercidin [1], have been isolated from the Fijian sponge Jaspis johnstoni. The structures were solved primarily by 13C nmr and mass spectral methods and confirmed by comparison to reported values in the literature. Small amounts of the corresponding aglycones were also isolated.

Original languageEnglish (US)
Pages (from-to)1353-1356
Number of pages4
JournalJournal of Natural Products
Volume52
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Toyocamycin
pyrimidine nucleosides
Pyrimidine Nucleosides
nucleosides
Porifera
Nucleosides
methodology
5-(methoxycarbonyl)tubercidin

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni. / Zabriskie, Mark; Ireland, Chris M.

In: Journal of Natural Products, Vol. 52, No. 6, 1989, p. 1353-1356.

Research output: Contribution to journalArticle

@article{487fa528db6547bd95308b8f45c1a1d6,
title = "The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni",
abstract = "Two cytotoxic pyrrolo[2,3-d]pyrimidine nucleosides, toyocamycin [2] and 5-(methoxycarbonyl)tubercidin [1], have been isolated from the Fijian sponge Jaspis johnstoni. The structures were solved primarily by 13C nmr and mass spectral methods and confirmed by comparison to reported values in the literature. Small amounts of the corresponding aglycones were also isolated.",
author = "Mark Zabriskie and Ireland, {Chris M.}",
year = "1989",
language = "English (US)",
volume = "52",
pages = "1353--1356",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "6",

}

TY - JOUR

T1 - The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni

AU - Zabriskie, Mark

AU - Ireland, Chris M.

PY - 1989

Y1 - 1989

N2 - Two cytotoxic pyrrolo[2,3-d]pyrimidine nucleosides, toyocamycin [2] and 5-(methoxycarbonyl)tubercidin [1], have been isolated from the Fijian sponge Jaspis johnstoni. The structures were solved primarily by 13C nmr and mass spectral methods and confirmed by comparison to reported values in the literature. Small amounts of the corresponding aglycones were also isolated.

AB - Two cytotoxic pyrrolo[2,3-d]pyrimidine nucleosides, toyocamycin [2] and 5-(methoxycarbonyl)tubercidin [1], have been isolated from the Fijian sponge Jaspis johnstoni. The structures were solved primarily by 13C nmr and mass spectral methods and confirmed by comparison to reported values in the literature. Small amounts of the corresponding aglycones were also isolated.

UR - http://www.scopus.com/inward/record.url?scp=0024947413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024947413&partnerID=8YFLogxK

M3 - Article

C2 - 2693614

AN - SCOPUS:0024947413

VL - 52

SP - 1353

EP - 1356

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 6

ER -