The intestinal microbiome in spondyloarthritis

Tejpal Gill, Mark Asquith, James T. Rosenbaum, Robert A. Colbert

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Purpose of review: Microbial dysbiosis in the gut is emerging as a common component in various inflammatory disorders including spondyloarthritis (SpA). The depth of this influence has begun to be realized with next-generation sequencing of the gut microbiome providing unbiased assessment of previously uncharted bacterial populations. Recent findings: Decreased numbers of Firmicutes, a major phyla of gut commensals, especially the species Faecalibacterium prausnitzii and Clostridium leptum have been found in various inflammatory disorders including SpA and inflammatory bowel disease (IBD), and could be an important link between SpA and gut inflammation. Multiple studies in ankylosing spondylitis, psoriatic arthritis, juvenile SpA, and animal models of SpA are revealing common bacterial associations among these diseases as well as IBD. Summary: We are beginning to appreciate the complex relationship between the gut microbiome and host immune regulation and dysregulation in health and disease. Potentially important differences have been revealed in SpA, but cause and effect relationships remain far from established. Many critical questions remain to be answered before we can apply new knowledge to improve therapeutics in SpA.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalCurrent opinion in rheumatology
Volume27
Issue number4
DOIs
StatePublished - Aug 24 2015
Externally publishedYes

Keywords

  • Ankylosing spondylitis
  • Dysbiosis
  • HLA-B27
  • Inflammatory bowel disease
  • Microbiome

ASJC Scopus subject areas

  • Rheumatology

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