The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation

Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

James L. Abbruzzese, Dana Andersen, Carl A.K. Borrebaeck, Suresh T. Chari, Eithne Costello, Zobeida Cruz-Monserrate, Guido Eibl, Edgar G. Engleman, William E. Fisher, Aida Habtezion, Seung K. Kim, Murray Korc, Craig Logsdon, Costas A. Lyssiotis, Stephen J. Pandol, Anil Rustgi, Bruce Wolfe, Lei Zheng, Alvin C. Powers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A workshop on "The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities" was held by the National Institute of Diabetes and Digestive and Kidney Diseases on October 12, 2017. The purpose of the workshop was to explore the relationship and possible mechanisms of the increased risk of pancreatic ductal adenocarcinoma (PDAC) related to diabetes, the role of altered intracellular energy metabolism in PDAC, the mechanisms and biomarkers of diabetes caused by PDAC, the mechanisms of the increased risk of PDAC associated with obesity, and the role of inflammatory events and mediators as contributing causes of the development of PDAC. Workshop faculty reviewed the state of the current knowledge in these areas and made recommendations for future research efforts. Further knowledge is needed to elucidate the basic mechanisms contributing to the role of hyperinsulinemia, hyperglycemia, adipokines, and acute and chronic inflammatory events on the development of PDAC.

Original languageEnglish (US)
Pages (from-to)516-525
Number of pages10
JournalPancreas
Volume47
Issue number5
DOIs
StatePublished - May 1 2018

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National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Pancreatic Neoplasms
Adenocarcinoma
Obesity
Inflammation
Education
Research
Adipokines
Hyperinsulinism
Hyperglycemia
Energy Metabolism
Biomarkers

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation : Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. / Abbruzzese, James L.; Andersen, Dana; Borrebaeck, Carl A.K.; Chari, Suresh T.; Costello, Eithne; Cruz-Monserrate, Zobeida; Eibl, Guido; Engleman, Edgar G.; Fisher, William E.; Habtezion, Aida; Kim, Seung K.; Korc, Murray; Logsdon, Craig; Lyssiotis, Costas A.; Pandol, Stephen J.; Rustgi, Anil; Wolfe, Bruce; Zheng, Lei; Powers, Alvin C.

In: Pancreas, Vol. 47, No. 5, 01.05.2018, p. 516-525.

Research output: Contribution to journalArticle

Abbruzzese, JL, Andersen, D, Borrebaeck, CAK, Chari, ST, Costello, E, Cruz-Monserrate, Z, Eibl, G, Engleman, EG, Fisher, WE, Habtezion, A, Kim, SK, Korc, M, Logsdon, C, Lyssiotis, CA, Pandol, SJ, Rustgi, A, Wolfe, B, Zheng, L & Powers, AC 2018, 'The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop', Pancreas, vol. 47, no. 5, pp. 516-525. https://doi.org/10.1097/MPA.0000000000001037
Abbruzzese, James L. ; Andersen, Dana ; Borrebaeck, Carl A.K. ; Chari, Suresh T. ; Costello, Eithne ; Cruz-Monserrate, Zobeida ; Eibl, Guido ; Engleman, Edgar G. ; Fisher, William E. ; Habtezion, Aida ; Kim, Seung K. ; Korc, Murray ; Logsdon, Craig ; Lyssiotis, Costas A. ; Pandol, Stephen J. ; Rustgi, Anil ; Wolfe, Bruce ; Zheng, Lei ; Powers, Alvin C. / The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation : Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. In: Pancreas. 2018 ; Vol. 47, No. 5. pp. 516-525.
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