The insulin‐like growth factor I generation test in the investigation of short stature

AM Cotterill, C. Camacho‐Hübner, K. Woods, C. Martinelli, P. Duquesnoy, MO Savage

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Genotypic and phenotypic heterogeneity in patients with growth hormone (GH) insensitivity syndrome suggests that partial defects exist in the GH receptor. The insulin‐like growth factor I (IGF‐I) generation test was assessed as a means of identifying partial GH receptor defects in a heterogeneous group of 22 prepubertal children with short stature. In a subgroup of nine patients with peak GH levels of 63.7 ± 3.7 mU/l during a glucagon tolerance test, the response to the IGF‐I generation test was no different from that for the group as a whole (peak GH, 43.3 ± 4.5 mU/l), despite the fact that this subgroup exhibited a negative relationship between height SDS and peak GH and a positive relationship between height SDS and IGF binding protein‐3. This preliminary study therefore suggests that the IGF‐I generation test in its present form will not be useful as a primary screening test for partial GH insensitivity. Despite this, the IGF‐I generation test has been extremely useful in the confirmation of the diagnosis of GHIS and may therefore also prove useful in the confirmation of partial defects in the GH receptor. A subgroup of short children with peak GH levels above 40 mU/l had some characteristics of partial GH receptor deficiency. These children, to whom GH therapy would not normally be given, may respond better to recombinant human IGF‐I.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalActa Pædiatrica
Volume83
DOIs
StatePublished - Apr 1994

Keywords

  • Growth hormone insensitivity syndrome
  • insulin‐like growth factor I generation test
  • partial GH receptor defects
  • short stature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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